533888-82-3

Basic information

• Product Name: benzyl {[3,5-bis(trifluoromethyl)phenyl]thio}acetate
• Synonyms: benzyl {[3,5-bis(trifluoromethyl)phenyl]thio}acetate
• CAS NO: 533888-82-3
• Molecular Weight: 394.337
• Mol File: 533888-82-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl {[3,5-bis(trifluoromethyl)phenyl]thio}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl {[3,5-bis(trifluoromethyl)phenyl]thio}acetate(533888-82-3)
• EPA Substance Registry System: benzyl {[3,5-bis(trifluoromethyl)phenyl]thio}acetate(533888-82-3)

Safety Data

• Hazardous Substances Data: 533888-82-3(Hazardous Substances Data)

Upstream product

• 130783-02-7 3,5-bis(trifluoromethyl)thiophenol 
• 5437-45-6 Benzyl bromoacetate 

Downstream Products

• 404825-82-7 benzyl {[3,5-bis(trifluoromethyl)phenyl]sulfonyl}acetate 

Relevant articles and documents

Synthesis and reactivity of π-electron-deficient (arylsulfonyl)acetates

Different π-electron-deficient (arylsulfonyl)acetates 9 were synthesized (Scheme 1, Table 1), and their behavior as soft nucleophiles in the dialkylation reaction under phase-transfer catalysis conditions was studied (Schemes 2 and 3, Tables 2 and 3). The [3,5-bis(trifluoromethyl)phenyl]sulfonyl group was shown to be the best substituent for the stereoselective synthesis of (E)-aconitates 18 via an alkylation hydro-sulfonyl-elimination integrated process under very mild phase-transfer-catalysis conditions (Scheme 5, Table 4). Sulfonylacetates 9h,i also underwent smooth Diels-Alder reactions with acyclic and cyclic dienes via in situ formation of the appropriate dienophile through a Knoevenagel condensation with paraformaldehyde (Scheme 6). Reductive desulfonylation with Zn and NH4Cl in THF was shown to be an efficient method for removal of the synthetically useful sulfonyl moiety (Scheme 7).