53390-12-8

Basic information

• Product Name: Benzofuran, 2-(2-chlorophenyl)-
• CAS NO: 53390-12-8
• Molecular Formula: C14H9ClO
• Molecular Weight: 228.678
• Mol File: 53390-12-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzofuran, 2-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 2-(2-chlorophenyl)-(53390-12-8)
• EPA Substance Registry System: Benzofuran, 2-(2-chlorophenyl)-(53390-12-8)

Safety Data

• Hazardous Substances Data: 53390-12-8(Hazardous Substances Data)

Upstream product

• 533-58-4 2-Iodophenol 
• 2039-87-4 2-chlorostyrene 
• 89122-63-4 (E)-2-(2-chlorostyryl)phenol 
• 873-31-4 2-chlorophenylacetylene 
• 32438-31-6 (2,2-diethoxy-ethoxy)-benzene 
• 108-95-2 phenol 
• 271-89-6 1-benzofurane 
• 14580-00-8 N’-(2-chlorophenyl)acetohydrazide 
• 694-80-4 2-bromo-1-chlorobenzene 
• 14714-50-2 2-hydroxybenzyl cyanide 
• 15946-36-8 2-chlorobenzenesulfinic acid sodium salt 
• 1447448-25-0 2-((2-chlorophenyl)ethynyl)phenol 
• 70340-04-4 (2-hydroxybenzyl)triphenylphosphonium bromide 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 1446486-56-1 2,3-bis(2-chlorophenyl)benzo[b]furan 

Relevant articles and documents

Acid-promoted selective synthesis of trifluoromethylselenolated benzofurans with Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate

A Br?nsted acid-promoted trifluoromethylselenolation of benzofurans was disclosed by using Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate as a stable and easily prepared electrophilic trifluoromethylselenolating reagent. A wide range of SeCF3-substituted benzofuran derivatives were obtained in moderate to good yields with excellent regioselectivity. The tandem cyclization/trifluoromethylselenolation procedure of 1-methoxy-2-(arylethynyl)benzenes were also realized by engaging FeCl3 as the catalyst.

Synthesis of benzofurans from terminal alkynes and iodophenols catalyzed by recyclable palladium nanoparticles supported on N,O-dual doped hierarchical porous carbon under copper- and ligand-free conditions

We herein report that a stable and recyclable heterogeneous catalyst, consisting of Pd nanoparticles supported on N,O-dual doped hierarchical porous carbon derived from naturally available and renewable biomass-bamboo shoots, which allows for highly efficient one-pot tandem reaction of o-iodophenols with terminal alkynes to synthesize biologically active 2-benzofuran derivatives under copper- and ligand-free conditions. The catalyst performed superior catalytic performance compared with the analogous Pd/C and supported on other metal oxides under otherwise identical conditions. A broad set of aryl and alkyl terminal alkynes can be effectively coupled /cyclized with various o-iodophenols to afford their corresponding 2-benzofurans in good to high yields with good tolerance of multiple functional groups. Moreover, the catalyst showed good stability and could be reused several times without significant loss of activity.

Transition-metal-free base catalyzed intramolecular cyclization of 2-ynylphenols for efficient and facile synthesis of 2-substituted benzo[b]furans

A transition-metal-free base catalyzed intramolecular cyclization of 2-ynylphenols was developed for the facile synthesis of 2-substituted benzo[b]furans. Various 2-aryl and 2-alkyl substituted benzo[b]furans can be obtained with good to excellent yields