53403-04-6

Basic information

• Product Name: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane
• Synonyms: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane
• CAS NO: 53403-04-6
• Molecular Weight: 132.205
• Mol File: 53403-04-6.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane(53403-04-6)
• EPA Substance Registry System: (+)-(1S,2S)-1-methyl-2-phenylcyclopropane(53403-04-6)

Safety Data

• Hazardous Substances Data: 53403-04-6(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 23020-15-7 (1S,2S)-2-phenylcyclopropane-1-carboxylic acid 
• 97-71-2 ethyl (S,S)-2-phenylcyclopropane-1-carboxylate 
• 51229-15-3 trans-(2-phenylcyclopropyl)carbinyl radical 
• 873-66-5 1-propenylbenzene 
• 75-11-6 diiodomethane 
• 64494-50-4 (η(5)-C5H5)(CO)2Fe-CH(OMe)Ph 
• 187737-37-7 propene 
• 75-07-0 acetaldehyde 
• 766-90-5 cis-1-phenyl-1-propylene 
• 240808-17-7 C₁₇H₁₈O 
• 142024-56-4 3-methoxy-2-methyl-3-phenyl-1-propene 
• 34008-94-1 tert-butyl ethyl sulfone 
• 56895-69-3 (cis-2,2-Dichloro-3-methylcyclopropyl)benzene 

Downstream Products

• 26278-68-2 1,3-dimethoxy-1-phenylbutane 
• 110659-48-8 (1'S,2'S)-1-(2'-methylcyclopropyl)-2-nitrobenzene 
• 87243-57-0 4-methyl-5-phenyl-2-isoxazoline 
• 7064-06-4 3-methyl-5-phenyl-4,5-dihydroisoxazole 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 79981-48-9 trans-(3-phenylcyclopropyl)methanol 
• 137601-87-7 p-(trans-2-Methylcyclopropyl)acetophenone 
• 137601-87-7 p-(cis-2-Methylcyclopropyl)acetophenone 
• 939-90-2 trans-2-phenylcyclopropane-1-carboxylic acid 
• 34271-31-3 trans-2-phenylcyclopropanecarbaldehyde 
• 35660-91-4 (E)-1-phenyl-2-buten-1-one 
• 6249-80-5 1-phenylbut-3-en-1-one 
• 61826-40-2 (2-phenylcyclopropyl)methanol 
• 874016-73-6 (1S,2R)-3-(2-methyl-1-cyclopropyl)-cyclohexa-3,5-diene-1,2-diol 

Relevant articles and documents

Mild Ring-Opening 1,3-Hydroborations of Non-Activated Cyclopropanes

The Brown hydroboration reaction, first reported in 1957, is the addition of B?H across an olefin in an anti-Markovnikov fashion. Here, we solved a long-standing problem on mild 1,3-hydroborations of non-activated cyclopropanes. A three-component system including cyclopropanes, boron halides, and hydrosilanes has been developed for borylative ring-opening of cyclopropanes following the anti-Markovnikov rule, under mild reaction conditions. Density functional theory (M06-2X) calculations show that the preferred pathway involves a cationic boron intermediate which is quenched by hydride transfer from the silane.

Cyclopropanation of alkenes with CH2I2/Et3Al by the phase-vanishing method based on fluorous phase screen

Phase-vanishing (PV) method using perfluorohexanes as a screen phase was applied to cyclopropanation reactions with CH2I2/Et2Zn and CH2I2/Et3Al. When Et3Al was used as a carbenoid generator, the reaction proceeded smoothly and desired cyclopropane derivatives were obtained in high yield. The PV cyclopropanation took 2 or 3 days to complete, however, reduction of reaction time by a factor of 2-3 was also achieved by vigorous stirring after the bottom CH2I2 layer disappeared.

Processing of cyclopropylarenes by toluene dioxygenase: Isolation and absolute configuration of metabolites

Several arenes possessing a cyclopropyl substituent were subjected to enzymatic oxidation with toluene dioxygenase. The absolute configuration of metabolites was established by chemical means.