53411-80-6

Basic information

• Product Name: 2-methoxy-4-methyl-6-nitrophenol
• Synonyms: 2-methoxy-4-methyl-6-nitrophenol
• CAS NO: 53411-80-6
• Molecular Weight: 183.164
• Mol File: 53411-80-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-methoxy-4-methyl-6-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-4-methyl-6-nitrophenol(53411-80-6)
• EPA Substance Registry System: 2-methoxy-4-methyl-6-nitrophenol(53411-80-6)

Safety Data

• Hazardous Substances Data: 53411-80-6(Hazardous Substances Data)

Upstream product

• 60-29-7 diethyl ether 
• 93-51-6 2-Methoxy-4-methylphenol 
• 7697-37-2 nitric acid 

Downstream Products

• 861620-12-4 4-acetoxy-3-methoxy-5-nitro-toluene 
• 78380-78-6 3,4-dimethoxy-5-nitro-toluene 
• 7509-10-6 4,5-dimethoxy-2,3-dinitro-toluene 
• 801183-86-8 3,4-dimethoxy-6-methyl-o-phenylenediamine 
• 871883-73-7 5.6-dinitro-creosol 
• 862730-25-4 2-amino-6-methoxy-4-methyl-phenol 
• 89791-96-8 5-methyl-3-nitrobenzene-1,2-diol 

Relevant articles and documents

Electrochemical Nitration with Nitrite

Aromatic nitration has tremendous importance in organic chemistry as nitroaromatic compounds serve as versatile building blocks. This study represents the electrochemical aromatic nitration with NBu4NO2, which serves a dual role as supporting electrolyte and as a safe, readily available, and easy-to-handle nitro source. Stoichiometric amounts of 1,1,1-3,3,3-hexafluoroisopropan-2-ol (HFIP) in MeCN significantly increase the yield by solvent control. The reaction mechanism is based on electrochemical oxidation of nitrite to NO2, which initiates the nitration reaction in a divided electrolysis cell with inexpensive graphite electrodes. Overall, the reaction is demonstrated for 20 examples with yields of up to 88 %. Scalability is demonstrated by a 13-fold scale-up.

POLYCYCLIC ANAPLASTIC LYMPHOMA KINASE INHIBITOR

Provided is a polycyclic inhibitor of anaplastic lymphoma kinase as represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R1, R2, R3, R4, and ring A are as defined in the description. The invention also relates to a method for preparing the compound, a pharmaceutical preparation and a pharmaceutical composition comprising the compound, and use of the compound, the pharmaceutically acceptable salt or stereoisomer thereof in manufacture of a medicament for the treatment and/or prevention of an anaplastic lymphoma kinase-mediated cancer or non-cancer related diseases.

A new method for the mononitration of phenol derivatives by poly(4-vinylpyridinium nitrate) and silica sulfuric acid under mild conditions

This procedure works efficiently for high selective mono nitration of phenol and substituted phenol to corresponding nitro compounds in moderate to high yield using poly(4-vinylpyridinium nitrate) and silica sulfuric acid in dichloromethane at room temperature.