53427-97-7

Basic information

• Product Name: 1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE
• Synonyms: 1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE;1-(4-nitrophenyl)-2(1H)-Pyridinone;1-(4-nitrophenyl)pyridin-2-one
• CAS NO: 53427-97-7
• Molecular Formula: C₁₁H₈N₂O₃
• Molecular Weight: 216.19282
• Mol File: 53427-97-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 188-189 °C(Solv: ethanol (64-17-5))
• Boiling Point: 439.543 °C at 760 mmHg
• Flash Point: 219.628 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.647
• PKA: -0.83±0.23(Predicted)
• CAS DataBase Reference: 1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE(53427-97-7)
• EPA Substance Registry System: 1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE(53427-97-7)

Safety Data

• Hazardous Substances Data: 53427-97-7(Hazardous Substances Data)

Usage

General Description

1-(4-Nitro-phenyl)-1H-pyridin-2-one is a chemical compound with the molecular formula C11H7N3O3. It is also known by its CAS number 101186-48-4. 1-(4-NITRO-PHENYL)-1H-PYRIDIN-2-ONE is a pyridine derivative with a nitrophenyl group attached to the pyridine ring, and a ketone group at position 2. It is commonly used in pharmaceutical and research applications, particularly in the development of drugs and other bioactive molecules. The nitro group in its structure makes it useful for various chemical reactions and synthetic purposes. It is important to handle this compound with care, as it may be hazardous if not used properly.

InChI:InChI=1/C11H8N2O3/c14-11-3-1-2-8-12(11)9-4-6-10(7-5-9)13(15)16/h1-8H

Upstream product

• 3902-84-9 potassium 2-oxo-2H-pyridin-1-ide 
• 100-00-5 4-chlorobenzonitrile 
• 142-08-5 2-hydroxypyridin 
• 636-98-6 p-nitrobenzene iodide 
• 142-08-5 2-Pyridone 
• 350-46-9 4-Fluoronitrobenzene 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 103983-87-5 1-(p-Nitrophenyl)-2-thiopyridon 
• 111015-93-1 1-(4-nitrophenyl)-3,5-dinitro-2-pyridone 
• 13663-59-7 N-(4-nitrophenyl)cyclohexylamine 
• 13143-47-0 1-(4-aminophenyl)pyridin-2(1H)-one 
• 438056-68-9 1-(4-aminophenyl)piperidine-2-one 

Relevant articles and documents

C(sp2)-H Trifluoromethylation of enamides using TMSCF3: Access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles

A method for the direct C(sp2)-H trifluoromethylation of enamides, including biologically relevant isoindolinones, isoquinolinones and 2-pyridinones using TMSCF3 under oxidative conditions is presented. The protocol is convenient, operationally simple and exhibits high tolerance across a multitude of relevant handles and functional groups.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Preparation of N-aryl pyridones

A novel process and intermediates thereof for making N-aryl pyridones of the type shown below from appropriate pyridinolates is described. These compounds are useful as intermediates for the synthesis of clinical candidates.