5344-20-7

Basic information

• Product Name: isohexylamine
• Synonyms: 4-methylpentan-1-amine
• CAS NO: 5344-20-7
• Molecular Formula: C₆H₁₅N
• Molecular Weight: 101.19
• Mol File: 5344-20-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 125°C at 760 mmHg
• Flash Point: 25.7°C
• Density: 0.768g/cm³
• Vapor Pressure: 12.4mmHg at 25°C
• Refractive Index: 1.42
• CAS DataBase Reference: isohexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: isohexylamine(5344-20-7)
• EPA Substance Registry System: isohexylamine(5344-20-7)

Safety Data

• Hazardous Substances Data: 5344-20-7(Hazardous Substances Data)

Usage

General Description

Isohexylamine, also known as 2-methyl-1-hexanamine, is a clear, colorless liquid with a strong ammonia-like odor. It is classified as an aliphatic amine, which is a chemical compound derived from ammonia (NH3) in which one or more of the hydrogen atoms are replaced by alkyl or aryl groups. Isohexylamine is commonly used as an intermediate in the production of pharmaceuticals, pesticides, and other organic compounds. It is also used as a corrosion inhibitor and as an intermediate in the manufacture of surfactants. Additionally, isohexylamine is used in the synthesis of rubber chemicals and as an industrial solvent. It is important to handle isohexylamine with caution, as it is corrosive and can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 1119-29-5 4-methyl-pentanamide 
• 857781-97-6 isohexyl-carbamic acid ethyl ester 
• 28659-90-7 (2S)-2-bromo-4-methylpentanenitrile 
• 7647-01-0 hydrogenchloride 
• 542-54-1 isocapronitrile 
• 61-90-5 L-leucine 
• 28659-87-2 (S)-2-bromo-4-methylpentanoic acid 
• 28659-88-3 chloride of/the/ L(-)-α-bromo-isocaproic acid 
• 28659-89-4 (2S)-2-bromo-4-methylpentanamide 
• 626-89-1 4-Methyl-1-pentanol 
• 21101-88-2 3-methylpentanenitrile 
• 646-07-1 4-Methylpentanoic acid 
• 38136-29-7 4-methylvaleroyl chloride 

Downstream Products

• 108899-61-2 N-isohexyl-2,4-dinitro-aniline 
• 30221-04-6 3-Benzyloxycarbonylamino-N-(4-methyl-pentyl)-succinamic acid benzyl ester 
• 76383-69-2 2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid (4-methyl-pentyl)-amide 
• 22274-67-5 N-(2,5-Methylen-1,2,5,6-tetrahydro-benzal)-isohexylamin 
• 22443-63-6 N-(2,5-Methylen-hexahydrobenzal)-isohexylamin 
• 853942-70-8 3-(4-methylpentyl)-4-phenyl-4-(trichloromethyl)-3,4-dihydroquinazolin-2(1H)-one 
• 62016-94-8 2-Methylpent-5-ylchlorid 
• 22459-47-8 N-(1-(Bicyclo<2.2.1>hepten-(5)-yl-(2))-2-phenyl-ethyl)-isohexylamin 
• 881384-15-2 5-[4-(2-Trifluoromethyl-benzoyl)-piperazin-1-yl]-[1,3,4]thiadiazole-2-carboxylic acid (4-methyl-pentyl)-amide 
• 123296-19-5 N-(3-hydroxy-4-methylpentyl)benzamide 
• 108262-66-4 5-amino-2-methylpentan-2-ol 
• 349098-69-7 N-(4-methylpentyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Two new insecticidal amides and a new alcoholic amide from Piper nigrum LINN

Three new amides, pipgulzarine (1), pipzorine (2), and piptahsine (3), have been isolated from the dried seeds of Piper nigrum LINN. along with nine known constituents: (2E,4E,8Z)-N-(isobutyl)eicosatrienamide, pellitorine, pipercide, piperine, stigmastanol, stigmasterol, decurrenal, stigmasterol 3-O-β-D-glucopyranoside, and 5,10(15)-cadinen-4-ol. The structures of the new constituents have been established as (2E,11E)-12(benzo[1,3]dioxol-5-yl)-N-(2-methylpropyl)dodeca-2,11-dienamide (1), (2E,12Z)-N-(4-methylpentyl)octadeca-2,12-dienamide (2), and (2E,4S)-4-hydroxy-N-(2-methylpropyl)hex-2-enamide (3). The structures of 1-3 were derived by spectral studies and chemical reactions, and by comparison of spectral data in the case of known constituents. Compounds 1 and 2, and most of the already known compounds, exhibited toxicity against fourth instar larvae of Aedes aegypti Liston. The isolated (Z) double bond in 2 was assigned on the basis of its EI-MS fragmentation pattern and its reaction with OsO4. The (S) configuration at C(4) of 3 was determined by Horeau's method. This is the first report of the isolation of a 4-methylpentylamide from P nigrum, while shorter branched amides have been reported from this genus [1].

Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

The site-selective functionalization of unactivated aliphatic amines is an attractive and challenging synthetic approach. We herein report a general strategy for the remote site-selective functionalization of unactivated C(sp3)-H bonds in amides by photogenerated amidyl radicals to form gem-difluoroalkenes with trifluoromethyl-substituted alkenes. The site selectivity is controlled by a 1,5-hydrogen atom transfer (HAT) process of the amide. This photocatalyzed transformation shows both chemo- and site-selectivity, facilitating the formation of a secondary, tertiary, or quaternary carbon center.

2-substituted parazoleamino-4-substituted amino-5-pyrimidine formamide compound, composition and application thereof

The invention relates to a series of new compounds as a JAK inhibitor, as well as compositions and applications thereof, and particularly provides a series of compounds (I) that have a strong JAK inhibiting activity, or stereisomers, geometrical isomers, tautomers, pharmaceutically acceptable salts, prodrugs, metabolites, isotope derivatives, and solvates, as well as medicine compositions comprising such compounds. The invention also discloses applications of the compounds or the medicine compositions in preparation of a medicine, which is used for treatment of autoimmune diseases or cancer.