5345-09-5

Basic information

• Product Name: 3,5-dimethyl-2-nitrophenol
• Synonyms: 3,5-Dimethyl-2-nitrophenol; Phenol, 3,5-dimethyl-2-nitro-
• CAS NO: 5345-09-5
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.162
• Mol File: 5345-09-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 265°C at 760 mmHg
• Flash Point: 115.7°C
• Density: 1.263g/cm³
• Vapor Pressure: 0.00573mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 3,5-dimethyl-2-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethyl-2-nitrophenol(5345-09-5)
• EPA Substance Registry System: 3,5-dimethyl-2-nitrophenol(5345-09-5)

Safety Data

• Hazardous Substances Data: 5345-09-5(Hazardous Substances Data)

Upstream product

• 108-68-9 3,5-Dimethylphenol 
• 73311-51-0 1-methoxy-3-methyl-1-trimethylsilyloxy-1,3-butadiene 
• 112825-86-2 ((Z)-1-Nitro-prop-1-ene-2-sulfinyl)-benzene 
• 60-29-7 diethyl ether 
• 7697-37-2 nitric acid 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 89586-10-7 methyl 2-acetoxy-4,6-dimethyl-3-nitrobenzoate 
• 28355-47-7 2-(3,5-dimethyl-phenoxy)-pyridine 

Downstream Products

• 23785-52-6 2,4-dimethyl-6-hydroxyaniline 
• 18102-38-0 2-nitro-3,5-dimethylanisole 
• 6538-39-2 dimethylpicric acid 
• 25674-51-5 2,4-dimethyl-6-hydroxythiophenol 
• 122443-58-7 4-nitrophenyl 2,4-dimethyl-6-hydroxyphenyl sulfide 
• 122443-57-6 4-nitrophenyl 2,4-dimethyl-6-methoxyphenyl sulfide 
• 122443-63-4 3,5-Dimethyl-2-(4-nitro-benzenesulfonyl)-phenol 
• 122443-62-3 1-Methoxy-3,5-dimethyl-2-(4-nitro-benzenesulfonyl)-benzene 
• 18087-07-5 2,4-dimethyl-6-methoxyaniline 
• 41772-27-4 1-acetoxy-2-acetylamino-3,5-dimethyl-benzene 
• 876475-75-1 N-(2-methoxy-4,6-dimethyl-phenyl)-diacetamide 
• 854672-42-7 2-amino-4,6-dibromo-3,5-dimethyl-phenol 
• 25674-57-1 2-methylthio-3,5-dimethylphenol 
• 25674-58-2 2-Etiltio-3,5-dimetil-fenolo 

Relevant articles and documents

A ortho-nitro phenol and its derivative synthesis method (by machine translation)

The invention relates to a method for the synthesis of organic compounds, in the existing technology of O-nitrophenol strong acid used in the synthesis process of the serious problem of environmental pollution and the synthesis step longer more complicated problem, the invention provides a ortho-nitro phenol and synthetic method of derivative thereof, proceeding by the phenol compound, synthesis of 2 - (phenoxy) pyridine, the obtained product, catalyst, tert-butyl nitrite, organic solvent and adding sealing in the pressure containers, in oil bath heating 50 - 100 °C, reaction 10 - 30 hours, to obtain 2 - (2 - nitrobenzene) ethoxy pyridine; re-processing by the ortho-nitro phenol and its derivatives; the method is simple, high-efficiency. (by machine translation)

Palladium-catalyzed aromatic C-H bond nitration using removable directing groups: Regiospecific synthesis of substituted o -nitrophenols from related phenols

A general and regiospecific transformation of substituted phenols into the related o-nitrophenols has been achieved via a three-step process involving the palladium-catalyzed chelation-assisted ortho-C-H bond nitration as the key step. In the process, 2-pyridinyloxy groups act as removable directing groups for the palladium-catalyzed ortho-nitration of substituted 2-phenoxypridines, and they can be readily removed in the subsequent conversion of the resulting 2-(2-nitrophenoxy)pyridines into 2-nitrophenols.

Nitration of substituted phenols by different efficient heterogeneous systems

Nitration of substituted phenols were carried out by the mixture of sodium nitrite and wet SiO2 (50% w/w) in the presence of four different efficient heterogeneous systems: 1) oxalic acid dihydrate (I), 2) sodium hydrogen sulphate (II), 3) aluminum hydrogen sulphate (III) and 4) silica sulphuric acid (IV) in CH2Cl2 at room temperature and high yields. Optimum conditions for theses systems and the regioselectivities of the reactions are reported.