53473-36-2

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
• Synonyms: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID;3-(4-(TRIFLUOROMETHYL)PHENYL)PROPANOIC ACID;3-[4-(TRIFLUOROMETHYL)PHENYL]PROPIONIC ACID;4-(Trifluoromethyl)HydrocinnamicAcid/P-(Trifluoromethyl)PhenylpropionicAcid/P-(Trifluoromethylphenyl)PropionicAcid;4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 95%;P-Trifluoromethyl benzylacetic acid;4-(TRIFLUOROMETHYL)PHENYLPROPIONIC ACID;4-(Trifluoromethyl)hydrocinnamic acid,95%
• CAS NO: 53473-36-2
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.17
• EINECS: 258-599-1
• Product Categories: Acids and Derivatives;Fluorine series
• Mol File: 53473-36-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 106-110 °C(lit.)
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: White to light brown/Crystalline Powder or Solid
• Density: 1.307 g/cm³
• Vapor Pressure: 0.00197mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.54±0.10(Predicted)
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID(53473-36-2)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID(53473-36-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 53473-36-2(Hazardous Substances Data)

Usage

Description

4-(Trifluoromethyl)hydrocinnamic Acid is a white to pale yellow crystalline powder with excellent bioactive properties. It is a chemical compound that has found applications in various industries due to its unique characteristics.

Uses

Used in Pharmaceutical Industry:
4-(Trifluoromethyl)hydrocinnamic Acid is used as a reagent for the synthesis of (poly)fluorinated neprilysin inhibitors, which are important in the development of medicines targeting specific enzyme inhibition.
Used in Pesticides Industry:
4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID is utilized in the formulation of pesticides, where its bioactive properties contribute to effective pest control and protection of crops.
Used in Dyes Industry:
4-(Trifluoromethyl)hydrocinnamic Acid is employed in the production of dyes, where its chemical properties enhance the color and stability of the final products.
Used in Functional Materials Preparation:
4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID is also used in the preparation of functional materials, where its bioactive properties are harnessed to create materials with specific characteristics and applications.

InChI:InChI=1/C10H9F3O2/c11-10(12,13)8-4-1-7(2-5-8)3-6-9(14)15/h1-2,4-5H,3,6H2,(H,14,15)

Upstream product

• 2062-26-2 3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid 
• 3984-22-3 2-vinyl-1,3-dioxolane 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 923977-13-3 2,2-dimethyl-5-(4-trifluoromethyl-benzyl)-[1,3]dioxane-4,6-dione 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 16642-92-5 4-(trifluoromethyl)cinnamic acid 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 79-10-7 acrylic acid 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 201230-82-2 carbon monoxide 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 292638-85-8 acrylic acid methyl ester 
• 3495-36-1 cesium formate 

Downstream Products

• 539855-79-3 3-<4-(trifluoromethyl)phenyl>propanoyl chloride 
• 849442-21-3 methyl 3-(4-(trifluoromethyl)phenyl)propanoate 
• 351014-62-5 vinyl 3-[4-(trifluoromethyl)phenyl]propanoate 
• 603998-97-6 2,2-dimethyl-5-{3-[4-(trifluoromethyl)phenyl]propanoyl}-1,3-dioxane-4,6-dione 
• 459872-43-6 N-[3-(4-trifluoromethylphenyl)propyl]-N-methylamine 
• 68755-37-3 6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one 
• 958666-90-5 4-nitrophenyl 3-[4-(trifluoromethyl)phenyl]propanoate 

Relevant articles and documents

Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer

A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra

Method for synthesizing phenylpropionic acid compounds through heterogeneous palladium metal catalysis

The invention discloses a method for synthesizing phenylpropionic acid compounds by heterogeneous catalysis. The method comprises the following steps: sequentially adding Pd@POL, toluene, styrene, formic acid and acetic anhydride into a reaction flask, stirring the reaction mixture at 80 DEG C to react, cooling the reaction solution to room temperature after the reaction is finished, diluting with dichloromethane, and transferring the solution into a separating funnel, washing with a sodium hydroxide solution, acidifying the water layer with a hydrochloric acid aqueous solution, extracting with dichloromethane, merging organic phases, drying with anhydrous sodium sulfate, and carrying out vacuum concentration to obtain the phenylpropionic acid compound. The method can remove heavy metal residues, is green and environment-friendly, is simple to operate and easy to implement, and the prepared phenylpropionic acid compound has a good application prospect.

Exploration of New Biomass-Derived Solvents: Application to Carboxylation Reactions

A range of hitherto unexplored biomass-derived chemicals have been evaluated as new sustainable solvents for a large variety of CO2-based carboxylation reactions. Known biomass-derived solvents (biosolvents) are also included in the study and the results are compared with commonly used solvents for the reactions. Biosolvents can be efficiently applied in a variety of carboxylation reactions, such as Cu-catalyzed carboxylation of organoboranes and organoboronates, metal-catalyzed hydrocarboxylation, borocarboxylation, and other related reactions. For many of these reactions, the use of biosolvents provides comparable or better yields than the commonly used solvents. The best biosolvents identified are the so far unexplored candidates isosorbide dimethyl ether, acetaldehyde diethyl acetal, rose oxide, and eucalyptol, alongside the known biosolvent 2-methyltetrahydrofuran. This strategy was used for the synthesis of the commercial drugs Fenoprofen and Flurbiprofen.