53473-83-9

Basic information

• Product Name: 3-(METHOXYMETHYL)ANILINE
• Synonyms: 3-(METHOXYMETHYL)ANILINE;AKOS MSC-0194;3-(Methoxymethyl)benzenamine;[3-(methoxymethyl)phenyl]amine sulfate (salt)
• CAS NO: 53473-83-9
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Mol File: 53473-83-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 229.385°C at 760 mmHg
• Flash Point: 97.175°C
• Appearance: /
• Density: 1.048g/cm³
• Vapor Pressure: 0.07mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-(METHOXYMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(METHOXYMETHYL)ANILINE(53473-83-9)
• EPA Substance Registry System: 3-(METHOXYMETHYL)ANILINE(53473-83-9)

Safety Data

• Hazardous Substances Data: 53473-83-9(Hazardous Substances Data)

Usage

General Description

3-(Methoxymethyl)aniline is a chemical compound with the molecular formula C9H13NO and a structure that consists of a benzene ring attached to an aniline group with a methoxymethyl substituent. It is primarily used as an intermediate in the production of various organic compounds, including dyes, pharmaceuticals, and agricultural chemicals. The chemical also has potential applications in the field of polymer chemistry and materials science. It is important to handle 3-(methoxymethyl)aniline with caution, as it may pose certain health and environmental risks due to its toxic and potentially hazardous nature.

InChI:InChI=1/C8H11NO/c1-10-6-7-3-2-4-8(9)5-7/h2-5H,6,9H2,1H3

Upstream product

• 1515-84-0 1-(methoxymethyl)-3-nitrobenzene 
• 74-83-9 methyl bromide 
• 619-25-0 3-Nitrobenzyl alcohol 
• 1877-77-6 3-aminobenzenemethanol 
• 74-88-4 methyl iodide 
• 619-23-8 3-Nitrobenzyl chloride 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 

Downstream Products

• 80936-72-7 3-[3-(3-Methoxymethyl-phenyl)-ureido]-benzenesulfonyl fluoride 
• 80936-71-6 4-[3-(3-Methoxymethyl-phenyl)-ureido]-benzenesulfonyl fluoride 
• 80936-81-8 3-[3-(3-Bromomethyl-phenyl)-ureido]-benzenesulfonyl fluoride 
• 80936-80-7 4-[3-(3-Bromomethyl-phenyl)-ureido]-benzenesulfonyl fluoride 
• 1260095-57-5 N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-4-nitroheptanediamide 
• 1260095-65-5 N-(3-bromomethylphenyl)-3,4-dihydroxybenzamide 
• 1260095-69-9 4-tert-butyl-1-(3-(3,4-dihydroxybenzamido)benzyl)pyridinium bromide 
• 1260095-61-1 N-(3-methoxymethylphenyl)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamide 
• 1260095-55-3 9H-fluoren-9-ylmethyl 1,7-bis(3-methoxymethylphenylamino)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-1,7-dioxoheptan-4-ylcarbamate 
• 1374643-76-1 4-methyl-N-(3-methoxymethyl-phenyl)-3-[4-(2,2,2-trifluoro-acetyl)-piperazin-1-yl]benzenesulfonamide 

Relevant articles and documents

Formation of highly charged quasi-molecular ions of a polycationic [60]fullerene hexakis-adduct and their fragmentation behavior in the gas phase

A novel polycationic [60]fullerene hexakis-adduct has been synthesized and investigated by electrospray ionization and tandem mass spectrometry. The polycationic ligand system comprises 12 pre-formed positive charges, compensated in the neutral molecule b

Efficient synthetic access to cationic dendrons and their application for ZnO nanoparticles surface functionalization: New building blocks for dye-sensitized solar cells

A new concept for the efficient synthesis of cationic dendrons, 4-tert-butyl-1-(3-(3,4-dihydroxybenzamido)benzyl)pyridinium bromide (17), 1,1′-(5-(3,4-dihydroxybenzamido)-1,3-phenylene)bis(methylene) bis(4-tert-butylpyridinium) bromide (18), N1,N7-bis(3-(

Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase

Trypanosoma brucei, the causative agent of African trypanosomiasis, contains a soluble, vacuolar pyrophosphatase, TbVSP1, not present in humans, which is essential for the growth of bloodstream forms in their mammalian host. Here, we report the inhibition of a recombinant TbVSP1 expressed in Escherichia coli by a panel of 81 bisphosphonates. The IC50 values were found to vary from ～2 to 850 μM. We then used 3D QSAR (comparative molecular field and comparative molecular similarity index; CoMFA and CoMSIA) methods to analyze the enzyme inhibition results. The R2 values for the experimental versus the QSAR-predicted activities were 0.78 or 0.61 for CoMFA and 0.79 or 0.68 for CoMSIA, for two different alignments. The root-mean-square (rms) pIC50 error for the best CoMFA model was 0.41 for five test sets of five activity predictions, which translates to a factor of ～2.6 error in IC50 prediction. For CoMSIA, the rms pIC50 error and error factors were 0.35 and 2.2, respectively. In general, the most active compounds contained both a single aromatic ring and a hydrogen bond donor feature. Thirteen of the more potent compounds were then tested in vivo in a mouse model of T. brucei infection. The most active compound in vivo provided a 40% protection from death with no apparent side effects, suggesting that further development of such compounds may be of interest.