53475-36-8

Basic information

• Product Name: 3-Pyridinecarbonitrile, 1,2-dihydro-4,6-dimethyl-2-oxo-1-phenyl-
• CAS NO: 53475-36-8
• Molecular Formula: C14H12N2O
• Molecular Weight: 224.262
• Mol File: 53475-36-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 1,2-dihydro-4,6-dimethyl-2-oxo-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 1,2-dihydro-4,6-dimethyl-2-oxo-1-phenyl-(53475-36-8)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 1,2-dihydro-4,6-dimethyl-2-oxo-1-phenyl-(53475-36-8)

Safety Data

• Hazardous Substances Data: 53475-36-8(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 7294-89-5 4-(phenylamino)pent-3-en-2-one 
• 109-77-3 malononitrile 
• 621-03-4 cyanoacetanilide 
• 123-54-6 acetylacetone 

Downstream Products

• 100870-28-8 4,6-dimethyl-2-oxo-1-phenyl-1,2-dihydro-pyridine-3-carboxylic acid amide 

Relevant articles and documents

2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development

As part of our effort to develop new molecular targeted antitumor drug, a novel 2,7-naphthyridone-based MET kinase inhibitor, 8-((4-((2-amino-3-chloropyridin-4-yl)oxy)- 3-fluorophenyl)amino)-2-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one (13f), was identif

Ionic liquid catalyzed 4,6-disubstituted-3-cyano-2-pyridone synthesis under solvent-free conditions

A green protocol for the synthesis of 4,6-disubstituted-3-cyano-2-pyridones from cyanoacetamides and 1,3-dicarbonyl compounds or chalcones using guanidine based ionic liquid as catalyst has been developed. In solvent-free conditions at 30 °C, [TMG][Lac] (1,1,3,3-tetramethylguanidine lactate) was found to have the highest catalytic activity among the ionic liquids including [TMG][Ac] (1,1,3,3-tetramethylguanidine acetate), [TMG][Pr] (1,1,3,3-tetramethylguanidine propionate), [TMG][n-Bu] (1,1,3,3-tetramethylguanidine n-butyrate) and [TMG][TFA] (1,1,3,3-tetramethylguanidine trifluoroacetate). The catalyst was recovered and recycled several times without significant loss of catalytic activity. Graphical Abstract: [Figure not available: see fulltext.]

The Reaction of β-Aminoenones with Substituted Acetonitriles. Regiospecific Synthesis of 2(1H)-Pyridones

Unsymmetrically substituted β-aminoenones react with malononitrile, cyanomethylphenylsulfone, benzoylacetonitrile and ethyl cyanoacetate, in very mild conditions, to yield regiospecifically 3-functionalized 2(1H)-pyridones in high yields.