5348-11-8

Basic information

• Product Name: 2-(4-CHLOROBENZYLIDENEAMINO)PHENOL
• Synonyms: 2-(4-CHLOROBENZYLIDENEAMINO)PHENOL
• CAS NO: 5348-11-8
• Molecular Formula: C₁₃H₁₀ClNO
• Molecular Weight: 0
• Mol File: 5348-11-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 397°C at 760 mmHg
• Flash Point: 193.9°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 7.15E-07mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 2-(4-CHLOROBENZYLIDENEAMINO)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROBENZYLIDENEAMINO)PHENOL(5348-11-8)
• EPA Substance Registry System: 2-(4-CHLOROBENZYLIDENEAMINO)PHENOL(5348-11-8)

Safety Data

• Hazardous Substances Data: 5348-11-8(Hazardous Substances Data)

Usage

Derivative of phenol

Contains a chlorobenzylideneamino group

Uses

Dye intermediate, production of pharmaceuticals and pesticides

Physical form

Yellow to brown crystalline powder

Solubility

Insoluble in water, soluble in organic solvents

Health hazards

Potential health risks, should be handled with care and proper safety protocols.

InChI:InChI=1/C13H10ClNO/c14-11-7-5-10(6-8-11)9-15-12-3-1-2-4-13(12)16/h1-9,16H/b15-9+

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 95-55-6 2-amino-phenol 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 88-75-5 2-hydroxynitrobenzene 

Downstream Products

• 1141-35-1 2-(4-chlorophenyl)benzoxazole 
• 13313-17-2 2-(4-chlorophenylmethyl)aminophenol 
• 148386-58-7 Ni(C₆H₄ONCHC₆H₄Cl)2 
• 148386-57-6 Pd(C₆H₄ONCHC₆H₄Cl)2 
• 248609-84-9 Ru(OC₆H₄CHNC₆H₃Cl)(P(C₆H₅)3)(CH₃OH)Cl 
• 248609-66-7 RuCl(P(C₆H₅)3)(OC₆H₄CHNC₆H₄Cl)2 
• 199463-95-1 Ru((C₅H₄N)2)2(OC₆H₄NCHC₆H₄Cl)⁽¹⁺⁾*ClO₄^(1-)=[Ru((C₅H₄N)2)2(OC₆H₄NCHC₆H₄Cl)]ClO₄ 
• 909554-14-9 [(N-(2'-hydroxyphenyl)-4-chlorobenzaldimine(-2H))(triphenylphosphine)2RhCl] 
• 952408-90-1 [Ru(PPh₃)2(CO)(N-(2'-hydroxyphenyl)-4-Cl-benzaldimine(-2H))] 
• 1197214-18-8 C₁₅H₁₂ClNO₂ 
• 1335242-67-5 C₂₁H₁₅ClN₂ 

Relevant articles and documents

Hemoglobin: A New Biocatalyst for the Synthesis of 2-substituted Benzoxazoles via Oxidative Cyclization

Efficient and mild synthesis of a series of 2-substituted benzoxazoles via oxidative cyclization catalyzed by hemoglobins reported here for the first time. Satisfactory yields (84 %–97 %) and mild reaction conditions make this method highly viable for practical applications.

Enantioselective Strecker and Allylation Reactions with Aldimines Catalyzed by Chiral Oxazaborolidinium Ions

Chiral oxazaborolidinium ion (COBI)-catalyzed enantioselective nucleophilic addition reactions of aldimines using tributyltin cyanide and allyltributylstannane have been developed. Various α-aminonitriles and homoallylic amines were synthesized in high yi

Oxidative NHC Catalysis for the Generation of Imidoyl Azoliums: Synthesis of Benzoxazoles

N-Heterocyclic carbene (NHC)-catalyzed intramolecular cyclization of aldimines generated from 2-amino phenols and aromatic aldehydes leading to the synthesis of 2-arylbenzoxazoles under mild conditions is presented. The reaction proceeds via the generation of the aza-Breslow intermediates from imines and NHC, which under oxidative conditions form the key imidoyl azoliums and a subsequent intramolecular cyclization furnishes the product. The reaction tolerates a broad range of functional groups, and the products are formed in generally good yields.