5352-63-6 Usage
Description
Digoxinigenin-mono(digitoxoside), also known as a steroid saponin, is a compound that consists of digoxigenin with a digitoxosyl residue attached at position 3. It is a white solid and is derived from the Digitalis plant, which has been used for its medicinal properties for centuries.
Uses
Used in Pharmaceutical Industry:
Digoxinigenin-mono(digitoxoside) is used as an active pharmaceutical ingredient for the treatment of heart conditions. It is particularly effective in managing heart failure and atrial fibrillation due to its ability to increase the force of heart muscle contractions and regulate heart rate.
Used in Research and Diagnostics:
In the field of research and diagnostics, digoxigenin-mono(digitoxoside) is used as a marker in various immunoassays and molecular biology techniques. Its high affinity for antibodies allows for the detection and quantification of specific target molecules, making it a valuable tool in scientific research and medical diagnostics.
Used in Drug Development:
Digoxinigenin-mono(digitoxoside) is also utilized in the development of new drugs, particularly those targeting heart-related conditions. Its unique chemical structure and pharmacological properties make it a promising candidate for the creation of novel therapeutic agents.
Used in Traditional Medicine:
In traditional medicine, digoxigenin-mono(digitoxoside) has been used for its various therapeutic properties, including its ability to treat heart-related ailments and its potential as a diuretic. Its long history of use and well-documented effects make it an important component in the development of traditional medicinal formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 5352-63-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,5 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5352-63:
(6*5)+(5*3)+(4*5)+(3*2)+(2*6)+(1*3)=86
86 % 10 = 6
So 5352-63-6 is a valid CAS Registry Number.
InChI:InChI=1/C29H44O8/c1-15-26(33)22(30)13-25(36-15)37-18-6-8-27(2)17(11-18)4-5-20-21(27)12-23(31)28(3)19(7-9-29(20,28)34)16-10-24(32)35-14-16/h10,15,17-23,25-26,30-31,33-34H,4-9,11-14H2,1-3H3/t15?,17-,18+,19-,20-,21+,22-,23-,25+,26-,27+,28+,29+/m1/s1
5352-63-6Relevant articles and documents
Effect of cyclodextrins on the acid hydrolysis of digoxin.
Uekama,Fujinaga,Hirayama,Otagiri,Kurono,Ikeda
, p. 627 - 630 (1982)
The effects of three cyclodextrins (alpha-, beta-, gamma-CyD) on the acid hydrolysis of digoxin were examined. From the high performance liquid chromatographic tracing of each of the four components (digoxin, bisdigitoxoside, monodigitoxoside, digoxigenin) in reaction mixtures, the individual rate constants (K1-K6) were determined by analogue computer simulation. The hydrolysis was suppressed by CyDs in the order of beta-great than gamma-greater than alpha-greater than-CyD, where beta-CyD inhibited the appearance rates of digoxigenin (k3, K5, and K6) significantly. In the dissolution study of digoxin tablets, the increase in dissolution rate and decrease in acid hydrolysis were attained by inclusion complexation. The data are presented suggesting that CyDs are useful for improving the oral bioavailability of digoxin.
Regioselective Schiff's base mediated deglycosidation of digitalis glycosides. New efficient synthesis of digoxigenin bis-digitoxoside and digoxigenin mono-digitoxoside
Adamczyk, Maciej,Grote, Jonathan
, p. 63 - 66 (2007/10/02)
Dialdehydes derived from digoxin glycosides via sodium periodate oxidation were regioselectively deglycosylated by various amino acids in anhydrous methanolic solution to afford excellent yields of digoxigenin bis-digitoxoside and digoxigenin mono-digitoxoside in a single step.
