5359-48-8

Basic information

• Product Name: 3,4-dichloro-N-(2-methyl-1-{4-methyl-5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}propyl)benzamide
• CAS NO: 5359-48-8
• Molecular Formula: C₁₅H₁₃BrO₂
• Molecular Weight: 463.4232
• Mol File: 5359-48-8.mol
• Article Data: 9

Chemical Properties

• Density: 1.31g/cm³
• Refractive Index: 1.636
• CAS DataBase Reference: 3,4-dichloro-N-(2-methyl-1-{4-methyl-5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}propyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dichloro-N-(2-methyl-1-{4-methyl-5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}propyl)benzamide(5359-48-8)
• EPA Substance Registry System: 3,4-dichloro-N-(2-methyl-1-{4-methyl-5-[(4-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}propyl)benzamide(5359-48-8)

Safety Data

• Hazardous Substances Data: 5359-48-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 21771-89-1 α-(4-bromophenyl)phenylacetic acid 
• 3262-89-3 triphenylboroxine 
• 264881-99-4 methyl 2-(4-bromophenyl)-2-diazoacetate 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 108-86-1 bromobenzene 
• 4870-65-9 2-bromophenylacetic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 29334-16-5 phenyl(4-bromophenyl)methanol 
• 13391-38-3 4-bromo-benzhydryl chloride 
• 33268-46-1 2-(4-bromophenyl)-2-phenylacetonitrile 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 75195-67-4 C₁₄H₁₃BrO 

Downstream Products

• 1070671-74-7 methyl 2-(4'-methoxybiphenyl-4-yl)-2-phenylacetate 
• 1070671-77-0 methyl 2-phenyl-2-(4-(3-(1,1-dioxidothiomorpholin-4-yl)prop-1-ynyl)phenyl)acetate 
• 1070671-83-8 methyl 2-phenyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)phenyl)acetate 
• 1423700-11-1 methyl 2-phenyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate 
• 1423701-90-9 C₂₁H₁₇BrO₂ 
• 1423689-30-8 C₃₄H₂₉ClN₂O₅ 
• 1423689-33-1 C₃₃H₂₇ClN₂O₅ 
• 1428526-76-4 2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid 
• 1428526-77-5 diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate 
• 1428526-75-3 diethyl 4-[(methoxycarbonyl)(phenyl)methyl]phenylphosphonate 

Relevant articles and documents

Room Temperature Coupling of Aryldiazoacetates with Boronic Acids Enhanced by Blue Light Irradiation

A visible-light-promoted photochemical protocol is reported for the coupling of aryldiazoacetates with boronic acids. This photochemical reaction shows great enhancement compared to the same protocol performed in the absence of light. Except for a few cases, the room temperature coupling in the dark (thermal process) generally does not work. When it does, it is likely to also involve free carbenes as key intermediates. Alternatively, photochemical reactions show a broad scope, can be performed under air and tolerate a wide variety of functional groups. Reaction-evolution monitoring, DFT calculations and control experiments have been used to evaluate the main aspects of this intricate mechanistic scenario. Biologically active molecules Adiphenine, Benactyzine and Aprophen have been prepared as examples of synthetic applications.

Rh(I)-catalyzed cross-coupling of α-diazoesters with arylsiloxanes

An Rh(I)-catalyzed cross-coupling of diazoesters with arylsiloxanes has been successfully achieved. This transformation is a new method for the construction of the C(sp3)-C(sp2) bond, thus providing an alternative synthesis of α-aryl esters. Rh(I)-carbene migratory insertion has been proposed to be involved in this coupling reaction. The reaction represents the first example of utilizing arylsiloxane as the coupling partner in the carbene-involved cross-coupling reactions.

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.