53618-42-1

Basic information

• Product Name: p-Methoxy-α-n-propylzimtsaeureaethylester
• CAS NO: 53618-42-1
• Molecular Weight: 248.322
• Mol File: 53618-42-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: p-Methoxy-α-n-propylzimtsaeureaethylester(CAS DataBase Reference)
• NIST Chemistry Reference: p-Methoxy-α-n-propylzimtsaeureaethylester(53618-42-1)
• EPA Substance Registry System: p-Methoxy-α-n-propylzimtsaeureaethylester(53618-42-1)

Safety Data

• Hazardous Substances Data: 53618-42-1(Hazardous Substances Data)

Upstream product

• 35051-49-1 2-diethoxyphosphoryl-pentanoic acid ethyl ester 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) δ-selective agonists

A series of 3-(4-alkoxyphenyl)propanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) δ-selective agonists, based on our previously discovered potent human PPARα/δ dual agonist TIPP-401 as a lead compound. Structure-activity relationship studies clearly indicated the importance of the chain length of the alkoxy group at the 4-position, and the n-butoxy compound exhibited the most potent PPARδ transactivation activity and highest PPARδ selectivity. The (S)-enantiomer of a representative compound exhibited extremely potent PPARδ transactivation activity, comparable with or somewhat superior to that of the known PPARδ-selective agonist, GW-501516. The representative compound regulated the expression of genes involved in lipid and glucose homeostasis, and should be useful not only as a chemical tool to study PPARδ function, but also as a candidate drug for the treatment of metabolic syndrome.