53646-85-8Relevant articles and documents
Iron-catalyzed sustainable synthesis of pyrrole
Emayavaramban, Balakumar,Sen, Malay,Sundararaju, Basker
, p. 6 - 9 (2017)
Efficient, sustainable, highly regiospecific substituted pyrroles were synthesized using a well-defined, air stable, molecular iron(0) complex. The developed methodology is broadly applicable and tolerates a variety of functional groups. C-2, C-3, and C-2 & C-4 substituted pyrroles were synthesized in good yield. Symmetrical bis-pyrroles were accessible for the first time using an iron catalyst. On the basis of the experimental observation, we propose that the reaction proceeds through a hydrogen autotransfer process followed by second oxidation/ intramolecular dehydrative condensation to provide the pyrrole.
Synthesis of Multisubstituted Pyrroles from Enolizable Aldehydes and Primary Amines Promoted by Iodine
Huang, Wenbo,Chen, Shaomin,Chen, Zhiyan,Yue, Meie,Li, Minghao,Gu, Yanlong
, p. 5655 - 5666 (2019/05/10)
1,2,4-Trisubstituted pyrroles were synthesized from enolizable aliphatic aldehydes and primary aliphatic amines by using iodine as the dual Lewis acid/mild oxidant. In the presence of 3.0 equiv of TBHP, enolizable α,β-unsaturated aldehyde, for example, co
A General Route to β-Substituted Pyrroles by Transition-Metal Catalysis
Bunrit, Anon,Sawadjoon, Supaporn,T?upova, Svetlana,Sj?berg, Per J. R.,Samec, Joseph S. M.
, p. 1450 - 1460 (2016/03/01)
An atom-efficient route to pyrroles substituted in the β-position has been achieved in four high yielding steps by a combination of Pd, Ru, and Fe catalysis with only water and ethene as side-products. The reaction is general and gives pyrroles substitute
