536725-68-5

Basic information

• Product Name: dithiophosphoric acid O-[6-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester S,S'-diphenyl ester
• Synonyms: dithiophosphoric acid O-[6-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester S,S'-diphenyl ester
• CAS NO: 536725-68-5
• Molecular Weight: 875.963
• Mol File: 536725-68-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dithiophosphoric acid O-[6-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester S,S'-diphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: dithiophosphoric acid O-[6-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester S,S'-diphenyl ester(536725-68-5)
• EPA Substance Registry System: dithiophosphoric acid O-[6-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl] ester S,S'-diphenyl ester(536725-68-5)

Safety Data

• Hazardous Substances Data: 536725-68-5(Hazardous Substances Data)

Upstream product

• 16658-10-9 2',3'-O-(methoxymethylidene)adenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 67941-87-1 cyclohexylammonium S,S-diphenyl phosphorodithioate 
• 536725-66-3 [(3aR,4R,6R,6aR)-6-(6-{[Bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-methanol 

Relevant articles and documents

Synthesis of TMG-capped RNA-DNA chimeric oligonucleotides

This paper deals with the synthesis of m32,2,7G5′pppAmpUmpApd(CpTpTpApCpCpT), a 5′-TMG-capped RNA-DNA chimeric oligonucleotide, which is expected to be conveyed to the nucleus by snurportin 1, a nuclear-transport protein. This 5′-TMG-capped RNA-DNA chimeric molecule was synthesized by the enzymatic condensation of m32,2,7G5′pppAmpUmpA with A5′ppd(CpTpTpApCpCpT) in the presence of RNA ligase. An inherent serious side reaction was disclosed in the 5′-adenylation of d(CpTpTpApCpCpT) on the solid support, but the use of an active ester intermediate as the pA donor gave an improved result.