53703-63-2

Basic information

• Product Name: 8-hydrazinyl-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
• CAS NO: 53703-63-2
• Molecular Formula: C₈H₁₂N₆O₂
• Molecular Weight: 224.2199
• Mol File: 53703-63-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 469.6°C at 760 mmHg
• Flash Point: 237.8°C
• Density: 1.66g/cm³
• Vapor Pressure: 5.44E-09mmHg at 25°C
• Refractive Index: 1.756
• CAS DataBase Reference: 8-hydrazinyl-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-hydrazinyl-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione(53703-63-2)
• EPA Substance Registry System: 8-hydrazinyl-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione(53703-63-2)

Safety Data

• Hazardous Substances Data: 53703-63-2(Hazardous Substances Data)

Upstream product

• 4921-49-7 8-chlorocaffeine 
• 10381-82-5 8-bromocaffeine 
• 58-08-2 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 

Downstream Products

• 4671-12-9 5,7,9-trimethyl-5,9-dihydro-[1,2,4]triazolo[4,3-e]purine-6,8-dione 
• 37789-28-9 8-Aminocaffeine 
• 110274-07-2 1,3,7,1',3',7'-hexamethyl-3,7,3',7'-tetrahydro-8,8'-(ethanediyl-bis-azo)-bis-purine-2,6-dione 
• 937789-36-1 C₁₆H₁₉N₇O₂S 

Relevant articles and documents

Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells

We report design and synthesis of set of novel anticancer agents based on caffeine-hydrazones bearing 2-hydroxyaryl- or 2-N-heteroaryl moiety. Anticancer activity evaluation using seven cancer cell lines and two non-malignant cell lines demonstrated that several derivatives display significant anticancer activity and great selectivity index toward T-lymphoblastic leukaemia cells. In general, hydrazones bearing 2-N-heteroaryl moiety are more active and selective than those with 2-hydroxyaryl moiety. Tested compounds exhibit dose-dependent inhibition of both RNA and DNA synthesis, with some exceptions. Antimicrobial activities were tested on set of twelve bacterial and yeast strains, however prepared compounds were not active, suggesting for a molecular target specific for eukaryotic cells.