53730-99-7

Basic information

• Product Name: 2-IODOBENZENE-1-SULFONAMIDE, 95%+
• Synonyms: 2-IODOBENZENE-1-SULFONAMIDE, 95%+
• CAS NO: 53730-99-7
• Molecular Formula: C₆H₆INO₂S
• Molecular Weight: 283.084
• Mol File: 53730-99-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 170℃
• Boiling Point: 389.2°C at 760 mmHg
• Flash Point: 189.2°C
• Appearance: /
• Density: 2.015g/cm³
• Vapor Pressure: 2.89E-06mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 2-IODOBENZENE-1-SULFONAMIDE, 95%+(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODOBENZENE-1-SULFONAMIDE, 95%+(53730-99-7)
• EPA Substance Registry System: 2-IODOBENZENE-1-SULFONAMIDE, 95%+(53730-99-7)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 53730-99-7(Hazardous Substances Data)

Usage

Description

2-IODOBENZENE-1-SULFONAMIDE, 95%+ is a chemical compound that features an iodine atom attached to a benzene ring and a sulfonamide group. It is widely recognized for its high purity of 95% or greater, making it an ideal candidate for research and industrial applications. This versatile compound is known for its reactivity with various reagents, allowing it to form new chemical bonds and participate in the synthesis of complex organic molecules.

Uses

Used in Pharmaceutical Industry:
2-IODOBENZENE-1-SULFONAMIDE, 95%+ is utilized as a building block in organic synthesis, specifically for the production of drugs and pharmaceutical intermediates. Its unique structure and reactivity make it a valuable component in the development of new medications and improving existing ones.
Used in Organic Synthesis:
In the field of organic synthesis, 2-IODOBENZENE-1-SULFONAMIDE, 95%+ is employed as a key component for creating a variety of complex organic molecules. Its ability to react with multiple reagents contributes to its broad application in this area, facilitating the formation of new chemical entities with potential uses in various industries.

InChI:InChI=1/C6H6INO2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,(H2,8,9,10)

Upstream product

• 63059-29-0 2-iodobenzene-1-sulfonyl chloride 
• 88-21-1 2-amino-1-benzenesulfonic acid 
• 63059-25-6 2-iodobenzenesulfonic acid 
• 146720-72-1 N-tert-butyl-2-iodobenzenesulphonamide 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 

Downstream Products

• 125259-04-3 C₁₂H₁₂N₂O₄S₃ 
• 883019-55-4 2-(2-Aminosulfonylphenylthio)benzoic acid 
• 22172-72-1 2-(phenylsulfanyl)benzenesulfonamide 
• 98-10-2 benzenesulfonamide 
• 259532-44-0 3-isopropyl-2H-1λ⁶-benzo[e][1,2]thiazine 1,1-dioxide 
• 935265-28-4 2-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)benzenesulfonamide 

Relevant articles and documents

Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors

A group of regioisomeric phenylethynylbenzenesulfonamides possessing a COX-2 SO2NH2 pharmacophore at the para-, meta- or ortho-position of the C-1 phenyl ring, in conjunction with a C-2 substituted-phenyl (H, OMe, OH, Me, F) group, w

Switchable Divergent Synthesis in Gold-Catalyzed Difunctionalizations of o-Alkynylbenzenesulfonamides with Aryldiazonium Salts

Gold-catalyzed difunctionalizations of o-alkynylbenzenesulfonamides with aryldiazonium salts are reported herein. Upon irradiation with the blue LEDs, benzosultam products were formed via aminoarylation accompanied by the release of N2. Without irradiatio

Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors

3-(4-Bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide (5) was discovered as a new prototype for dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). Thus, the structure-activity relationships of benzo[1.3.2]dithiazolium ylide 1,1-dioxide skeleton were carried out. The 6-NO2 group played an essential role in the inhibitory activity. In addition, moderate-sized lipophilic substituents at the para-position of the 3-aryl moiety were required for dual COX-2/5-LOX inhibitory activity. Among the identified potent dual inhibitors, 3-(4-tbutylphenyl) derivative 30c (IC50 values of 0.27 μM and 0.30 μM against COX-2 and 5-LOX, respectively) and 3-(4-biphenyl) derivative 30f (IC50 values of 0.50 μMand 0.15 μMagainst COX-2 and 5-LOX, respectively) were the most potent dual COX-2/ 5-LOX inhibitors. Intraperitoneal administration of 30c at 100 mg/kg demonstrated potent acute antiinflammatory activity. As a result, benzo[1.3.2]dithiazolium ylide 1,1-dioxide represented a novel scaffold for the exploitation in developing dual COX-2/5-LOX inhibitors.