53733-94-1

Basic information

• Product Name: Methyl 3-[(3-methoxy-3-oxopropyl)phenylamino]propanoate
• Synonyms: N,N-DIMETHOXY CARBONYL ETHYL ANILINE;methyl N-(3-methoxy-3-oxopropyl)-N-phenyl-beta-alaninate;N,N-bis(3-methoxy-3-oxopropyl)benzenamine;N,N-DI(2-METHOXYCARBONYL )ANILINE;N,N-Bis-[2-(methoxycarbonyl)-ethyl]-aniline;Methyl 3-[(3-methoxy-3-oxopropyl)phenylamino]propanoate;3,3'-(Phenylimino)bis(propanoic acid methyl) ester;N-(3-Methoxy-3-oxopropyl)-N-phenyl-β-alanine methyl ester
• CAS NO: 53733-94-1
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.3
• EINECS: 258-731-8
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 53733-94-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 372.3 °C at 760 mmHg
• Flash Point: 179 °C
• Appearance: /
• Density: 1.136 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-[(3-methoxy-3-oxopropyl)phenylamino]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-[(3-methoxy-3-oxopropyl)phenylamino]propanoate(53733-94-1)
• EPA Substance Registry System: Methyl 3-[(3-methoxy-3-oxopropyl)phenylamino]propanoate(53733-94-1)

Safety Data

• Hazardous Substances Data: 53733-94-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-[(3-methoxy-3-oxopropyl)phenylamino]propanoate is a compound that belongs to the family of esters, which are organic compounds commonly used in fragrances, flavorings, and pharmaceuticals. This particular chemical consists of a three-carbon propanoate chain with a methyl group and an amine group, as well as a phenyl ring with a methoxy and oxopropyl substituent. Its molecular structure suggests that it can potentially function as a flavoring or fragrance agent due to the presence of the aromatic phenyl group, as well as a pharmaceutical intermediate for the synthesis of other compounds. However, further research and analysis are necessary to determine its specific applications and potential uses in various industries.

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 62-53-3 aniline 
• 108-91-8 cyclohexylamine 
• 3395-91-3 Methyl 3-bromopropionate 

Downstream Products

• 52766-37-7 N-ethoxycarbonyl-N-phenyl-β-alanine 
• 7501-80-6 C₁₃H₁₅NO₃ 
• 1450610-24-8 C₁₂H₁₃N₃O₂ 
• 1190761-85-3 3,3′-(2,2′-(phenylazanediyl)bis(ethane-2,1-diyl))bis-(4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide) 
• 56329-74-9 3,3′-(phenylazanediyl)dipropanehydrazide 
• 94111-82-7 4--benzaldehyd 

Relevant articles and documents

Study on a series of water-soluble photoinitiators for fabrication of 3D hydrogels by two-photon polymerization

A series of water-soluble benzylidene cyclanone dyes T1-T3 were synthesized. Their photo-physical properties were investigated using UV–Vis spectra, fluorescence spectra and two-photon absorption spectra. The maximum two-photon absorption cross-sections (σ2) of T1-T3 in deionized water were determined as 567?GM, 808?GM and 231?GM. Using T1-T3 as photoinitiators (PIs) directly, 2D and 3D nano patterns based on two-photon crosslinking or polymerization of bovine serum albumin (BSA), water-soluble acrylic ester monomer (SR610) and hyaluronic acid derivative (HAGM) were successfully fabricated, respectively. Much lower threshold energies and wider fabrication windows were obtained in the formulations containing these PIs compared with commercial ones. Furthermore, the cytotoxicity study showed a favorable biocompatibility of these PIs, which indicated T1-T3 would have application prospects in 3D fabrication of biomaterials.

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA- methyltransferase, DNA mismatch repair, and p53

The antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C. 2.1.1.63, MGMT). Tumor response is also dependent on wild-type p53. Novel 3-(2-anilinoethyl)-substituted imidazotetrazines are reported that have activity independent of MGMT, MMR, and p53. This is achieved through a switch of mechanism so that bioactivity derives from imidazotetrazine-generated arylaziridinium ions that principally modify guanine-N7 sites on DNA. Mono- and bifunctional analogues are reported, and a quantitative structure-activity relationship (QSAR) study identified the p-tolyl-substituted bifunctional congener as optimized for potency, MGMT-independence, and MMR-independence. NCI60 data show the tumor cell response is distinct from other imidazotetrazines and DNA-guanine-N7 active agents such as nitrogen mustards and cisplatin. The new imidazotetrazine compounds are promising agents for further development, and their improved in vitro activity validates the principles on which they were designed.

An efficient ZrCl4 catalyzed aza-michael addition reaction: Synthesis of C-linked carbo β3-amino acids

A mild aza-Michael protocol has been developed using ZrCl4 as catalyst on α, β-unsaturated esters and nitriles. The aromatic amines were found to give the products with ease. The ZrCl4 mediated route was compatible with acid sensitive carbohydrate esters and provided an efficient method to prepare C-linked carbo β3-amino acids (β3-Caa).