53761-46-9 Usage
Type of compound
Dye
Usage
Medical and biological research
Function
Fluorescent marker for protein aggregation and fibril formation
Specific application
Studies related to Alzheimer's disease and other neurodegenerative disorders
Affinity
High affinity for amyloid fibrils
Binding property
Emits a strong fluorescent signal when bound to amyloid structures
Utility
Visualization and quantification of protein aggregates
Research focus
Understanding the mechanisms of amyloid formation
Relevance
Development of potential therapeutics for amyloid-related diseases
Check Digit Verification of cas no
The CAS Registry Mumber 53761-46-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,6 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 53761-46:
(7*5)+(6*3)+(5*7)+(4*6)+(3*1)+(2*4)+(1*6)=129
129 % 10 = 9
So 53761-46-9 is a valid CAS Registry Number.
53761-46-9Relevant articles and documents
Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones
Daniliuc, Constantin,Glorius, Frank,Hu, Tianjiao,Lückemeier, Lukas
, p. 23193 - 23196 (2021/09/25)
Direct enantioselective hydrogenation of unsaturated compounds to generate chiral three-dimensional motifs is one of the most straightforward and important approaches in synthetic chemistry. We realized the Ru(II)-NHC-catalyzed asymmetric hydrogenation of 2-quinolones under mild reaction conditions. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones were obtained in high yields with moderate to excellent enantioselectivities. The reaction provides an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.
