537697-28-2

Basic information

• Product Name: O-Methyl-D-threonine
• Synonyms: H-D-Thr(Me)-OH;O-Methyl-D-threonine;(2R,3S)-2-Amino-3-methoxybutanoic acid
• CAS NO: 537697-28-2
• Molecular Formula: C₅H₁₁NO₃
• Molecular Weight: 133.14574
• Mol File: 537697-28-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: O-Methyl-D-threonine(CAS DataBase Reference)
• NIST Chemistry Reference: O-Methyl-D-threonine(537697-28-2)
• EPA Substance Registry System: O-Methyl-D-threonine(537697-28-2)

Safety Data

• Hazardous Substances Data: 537697-28-2(Hazardous Substances Data)

Usage

General Description

O-Methyl-D-threonine is a chemical compound with the molecular formula C5H11NO3. It is an amino acid derivative that contains a methyl group attached to the oxygen atom of the threonine molecule. O-Methyl-D-threonine is primarily used as a building block in the synthesis of various natural products and pharmaceuticals. O-Methyl-D-threonine has potential applications in the development of therapeutics for conditions such as cancer, bacterial infections, and neurological disorders. Additionally, it plays a crucial role in the production of antibiotics, antitumor agents, and other biologically active substances. Overall, O-Methyl-D-threonine has significant importance in the fields of medicine and drug development due to its versatile chemical structure and functional properties.

Upstream product

• 7505-36-4 N-formyl-O-methyl-D^s-threonine 
• 2076-53-1 O-methyl-DL-threonine 
• 6622-23-7 N-formyl-O-methyl-DL-threonine 
• 544480-12-8 methyl (2R,3S)-2-(tert-butoxycarbonylamino)-3-methoxybutanoate 

Relevant articles and documents

Minutissamides E-L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp.

The extract of UIC 10035, a strain obtained from a sample collected near the town of Homestead, South Florida, showed antiproliferative activity against MDA-MB-435 cells. Bioassay-guided fractionation led to the isolation of a series of cyclic lipodecapeptides, named minutissamides E-L (1-8). The planar structures were determined by analysis of HRESIMS, tandem MS, and 1D and 2D NMR data, and the stereoconfigurations were assigned by LC-MS analysis of the Marfey's derivatives after acid hydrolysis. Minutissamides E-L (1-8) exhibited antiproliferative activity against MDA-MB-435 cells with IC50 values ranging between 1 and 10 μM. The structures of minutissamides E-L (1-8) were closely related with those of the previously reported lipopeptides, puwainaphycins A-E and minutissamides A-D, characterized by the presence of a lipophilic β-amino acid and three non-standard amino acids NMeAsn, OMeThr and Dhb (α,β-dehydro-α-aminobutyric acid). The strain UIC 10035 was designated as cf. Anabaena sp. on the basis of morphological and 16S rRNA gene sequence analyses.