53778-26-0Relevant articles and documents
Praparation of Ethyl 3,5-Disubstituted Pyrrole-2-carboxylates from 1,3-Diketones and Ethyl Glycinate Hydrochloride
Mataka, Shuntaro,Takahashi, Kazufumi,Tsuda, Yuhsuke,Tashiro, Masashi
, p. 157 - 159 (1982)
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DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles
Yang, Tianyu,Wang, Ke-Hu,Huang, Danfeng,Li, Pengfei,Deng, Zhoubin,Su, Yinpeng,Hu, Yulai
, p. 2291 - 2297 (2019/03/06)
An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various α,β-unsaturated ynones reacted with N-substituted ethyl glycine ethyl ester hydrochlorides in the presence of DBU to form the co
Transition Metal-Free Synthesis of 3-Alkynylpyrrole-2-carboxylates via Michael Addition/Intramolecular Cyclodehydration
Teng, Qing-Hu,Xu, Yan-Li,Liang, Ying,Wang, Heng-Shan,Wang, Ying-Chun,Pan, Ying-Ming
supporting information, p. 1897 - 1902 (2016/07/06)
A transition metal-free and efficient method for the synthesis of 3-alkynylpyrrole-2-carboxylates from diynones and glycine esters or 2-aminoacetophenone hydrochloride has been developed. This transformation provides a large range of substituted pyrroles in good to excellent yields with the elimination of water as the only by-product. The detailed mechanistic studies elucidated that this transformation involves a Michael addition/intramolecular cyclodehydration process. (Figure presented.) .