5378-49-4

Basic information

• Product Name: 5-AMINO-1H-TETRAZOLE
• Synonyms: AURORA KA-6577;1-Aminotetrazole;5-Amino Tetrazole anhydrous;1H-Tetrazol-1-amine
• CAS NO: 5378-49-4
• Molecular Formula: CH₃N₅
• Molecular Weight: 85.07
• EINECS: 224-581-7
• Product Categories: Tetrazoles
• Mol File: 5378-49-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 201-205 °C(lit.)
• Boiling Point: 273℃
• Flash Point: 119℃
• Appearance: /
• Density: 2.06
• Refractive Index: 2.1050 (estimate)
• PKA: 1.73±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1H-TETRAZOLE(5378-49-4)
• EPA Substance Registry System: 5-AMINO-1H-TETRAZOLE(5378-49-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• RTECS: XF7465000
• Hazardous Substances Data: 5378-49-4(Hazardous Substances Data)

Usage

General Description

5-amino-1H-tetrazole is a heterocyclic organic compound with the chemical formula C2H4N6. It is a white, crystalline solid and is commonly used in the synthesis of pharmaceuticals and energetic materials. 5-AMINO-1H-TETRAZOLE is highly explosive and should be handled with extreme care. It has been used as a propellant for airbag inflators and in the production of azoles, which are important in the pharmaceutical industry. 5-amino-1H-tetrazole has also been studied for its potential use as a cyanide antidote due to its ability to form a stable complex with cyanide ions. However, its high reactivity and explosive nature limit its use and require strict safety precautions.

Upstream product

• 5378-50-7 1-benzylideneaminotetrazole 
• 14094-78-1 5H-tetrazole 
• 288-94-8 1H-tetrazole 

Downstream Products

• 1222860-98-1 5-{4-[2-(4-Chlorobenzenesulphonamido)-ethyl]-phenyl}-pentanoic acid (1H-tetrazol-5-yl)-amide 

Relevant articles and documents

SIMPLE SYNTHESIS OF 1-AMINOTETRAZOLE

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Maximization of the energy capability level in transition metal complexes through application of 1-amino- and 2-amino-5: H -tetrazole ligands

Toxic lead compounds (especially lead azide and lead styphnate), reliable but highly harmful compounds, still dominate the field of primary explosives used in most ignition and initiation systems to this day. Therefore, an extensive investigation into energetic materials with similar performance and minimized toxicity led to the very promising strategy of developing energetic coordination compounds (ECC). For the first time in literature, two isomeric amino-5H-tetrazoles with sensitivities already in the range of primaries, which could be obtained via practicable, easily scalable synthesis, proved to be very promising new energetic ECC ligands. By variation of the respective isomer (1-AT, 2-AT), metal(ii) center (MnII, FeII, CuII, ZnII) and the corresponding counter-anion (Cl-, NO3-, ClO3-, ClO4-, styphnate, trinitrophloroglucinate) desired properties could be tailored gradually, yielding 20 new, highly energetic and easily accessible transition metal(ii) complexes. In addition to comprehensive characterization by XRD, IR, EA, solid-state UV/Vis, DTA and TGA, BAM standard sensitivity measurements as well as ESD and ball drop impact sensitivities were determined. Classical initiation tests (nitropenta filled detonator) validated the present approach to be extraordinarily promising for potential use in advanced initiation systems. Beyond successfully achieving set goals in terms of sensitivity and toxicity, investigated complexes match or even outperform lead-based primaries' high performance and, more importantly, do not necessarily depend on initiation by mechanical stimuli. Laser irradiation of the received primary explosives with near-infrared light (NIR) yielded initiation reliably and safely, further extending their potential for future applications.

3-substituted cephem compounds

The present invention relates to novel cephalosporins of the formula (I); STR1 wherein, R1 represents a C1 ?C4 alkyl group or STR2 wherein, R2 and R3, independently, represent hydrogen or a C1 ?C3 alkyl group and R4 represents hydrogen or a C1 ?C4 alkyl group; R1a represents hydrogen or an amino-protecting group; Q represents CH or N; and the formula STR3 represents a saturated or unsaturated heterocyclic group which contains 1 to 4 nitrogen atoms of which one is substituted with an amino group to form quaternary ammonium, and oxygen or sulfur, or a fused heterocyclic group thereof formed together with a substituted or unsubstituted benzene or an optional heterocyclic group, or a pharmaceutically acceptable salt thereof, to processes for preparing the same and to a pharmaceutical composition containing the same as an active ingredient. The compounds(1) according to the invention exhibit potent antibacterial activity and broad antibacterial spectrum against the Gram-positive strains including Staphylococcus as well as Gram-negative strains including Pseudomonas, and, therefore, are expected to be very useful in treatment of various diseases caused by bacterial infection in human beings and animals.