53783-57-6Relevant articles and documents
Hf-MOF catalyzed Meerwein?Ponndorf?Verley (MPV) reduction reaction: Insight into reaction mechanism
Lin, Yamei,Bu, Qingxia,Xu, Jiaxian,Liu, Xiao,Zhang, Xueping,Lu, Guo-Ping,Zhou, Baojing
, (2021)
Hf-MOF-808 exhibits excellent activity and specific selectivity on the hydrogenation of carbonyl compounds via a hydrogen transfer strategy. Its superior activity than other Hf-MOFs is attributed to its poor crystallinity, defects and large specific surface area, thereby containing more Lewis acid-base sites which promote this reaction. Density functional theory (DFT) computations are performed to explore the catalytic mechanism. The results indicate that alcohol and ketone fill the defects of Hf-MOF to form a six-membered ring transition state (TS) complex, in which Hf as the center of Lewis stearic acid coordinates with the oxygen of the substrate molecule, thus effectively promoting hydrogen transfer process. Other reactive groups, such as –NO2, C = C, -CN, of inadequate hardness or large steric hindrance are difficult to coordinate with Hf, thus weakening their catalytic effect, which explains the specific selectivity Hf-MOF-808 for reducing the carbonyl group.
Convenient in situ generation of various dichlorinating agents from oxone and chloride: Diastereoselective dichlorination of allylic and homoallylic alcohol derivatives
Ren, Jingyun,Tong, Rongbiao
supporting information, p. 4312 - 4315 (2013/08/23)
A safe and convenient protocol was developed for in situ generation of various dichlorinating agents (cf. Cl2, NCl3, Et 4NCl3, ArICl2) from oxone and chloride. The synthetic utility of this protocol was demonstrated by diastereoselective dichlorination of a series of allylic and homoallylic alcohol derivatives with excellent yields and diastereoselectivity. The Royal Society of Chemistry 2013.
Reduction of α-Chlorocarbonyl Compounds by the Tributyltin Hydride-Phosphine Oxide Combined System. Chemoselective Reduction of the Carbonyl Group
Shibata, Ikuya,Suzuki, Taro,Baba, Akio,Matsuda, Haruo
, p. 882 - 883 (2007/10/02)
α-Chlorocarbonyl compounds undergo selective reduction at the carbonyl group with tributyltin hydride-phosphine oxide combined systems to yield chlorohydrins.
