5379-97-5

Basic information

• Product Name: diethyl (acetylamino)(1H-indol-3-ylmethyl)propanedioate
• Synonyms: Diethyl acetamido(1H-indol-3-ylmethyl)malonate; propanedioic acid, 2-(acetylamino)-2-(1H-indol-3-ylmethyl)-, diethyl ester
• CAS NO: 5379-97-5
• Molecular Formula: C₁₈H₂₂N₂O₅
• Molecular Weight: 346.3777
• Mol File: 5379-97-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 551.3°C at 760 mmHg
• Flash Point: 287.2°C
• Density: 1.238g/cm³
• Vapor Pressure: 3.36E-12mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: diethyl (acetylamino)(1H-indol-3-ylmethyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (acetylamino)(1H-indol-3-ylmethyl)propanedioate(5379-97-5)
• EPA Substance Registry System: diethyl (acetylamino)(1H-indol-3-ylmethyl)propanedioate(5379-97-5)

Safety Data

• Hazardous Substances Data: 5379-97-5(Hazardous Substances Data)

Upstream product

• 87-52-5 3-(Dimethylaminomethyl)indole 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 22687-14-5 3-(tert-butyliminomethine)indole 
• 5457-31-8 (3-indolylmethyl)trimethylammonium iodide 
• 30412-43-2 sodium diethylacetamidomalonate 
• 6297-96-7 acetylamino-(3-phenylhydrazono-propyl)-malonic acid diethyl ester 
• 620598-21-2 (N-triisopropylsilyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodide 
• 120-72-9 indole 
• 50624-64-1 3-(bromomethyl)-1H-indole 
• 13433-00-6 diethyl aminomalonate hydrochloride 

Downstream Products

• 6976-19-8 acetylamino-(1-methyl-indol-3-ylmethyl)-malonic acid diethyl ester 
• 1218-34-4 N-acetyl-DL-tryptophan 
• 42717-06-6 acetyltryptophan ethylester 
• 26988-72-7 2-amino-3-(1-methyl-1H-indol-3-yl)-propanoic acid 
• 54-12-6 Trp 
• 10022-82-9 D,L-1-Methyl-3,4-dihydro-β-carboline-3-carboxylic acid 
• 22223-38-7 N^α-Ethoxycarbonyl-tryptophan 

Relevant articles and documents

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Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines

With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox-active esters (RAEs) to isoquinolines has been developed. A variety of prochiral α-aminoalkyl radicals generated from RAEs were successfully introduced on isoquinolines, providing a range of valuable α-isoquinoline-substituted chiral secondary amines in high yields with good to excellent enantioselectivities.

Selective mono-alkylation of carbon nucleophiles with gramine

Mono-alkylation method of carbon nucleophiles, especially for nitroalkanes, with gramine derivatives is reported