53803-91-1

Basic information

• Product Name: 1-(4,5-Dichloro-2-Methylphenyl)ethanone
• Synonyms: 1-(4,5-Dichloro-2-Methylphenyl)ethanone;2-methyl-4,5-dichloroacetophenone
• CAS NO: 53803-91-1
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.06522
• Mol File: 53803-91-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4,5-Dichloro-2-Methylphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4,5-Dichloro-2-Methylphenyl)ethanone(53803-91-1)
• EPA Substance Registry System: 1-(4,5-Dichloro-2-Methylphenyl)ethanone(53803-91-1)

Safety Data

• Hazardous Substances Data: 53803-91-1(Hazardous Substances Data)

Usage

General Description

1-(4,5-Dichloro-2-Methylphenyl)ethanone, also known as 1-(4,5-Dichloro-2-Methylphenyl)ethanone, is a chemical compound with the molecular formula C9H8Cl2O. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1-(4,5-Dichloro-2-Methylphenyl)ethanone has a wide range of applications, including its use as a building block in organic synthesis and as a reagent in various chemical reactions. It is important to handle this chemical with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system. Additionally, it has the potential to cause environmental harm if not properly managed and disposed of.

Upstream product

• 95-75-0 3,4-Dichlorotoluene 
• 75-36-5 acetyl chloride 
• 7446-70-0 aluminium trichloride 

Downstream Products

• 854871-43-5 7-chloro-2-(4,5-dichloro-2-methyl-phenyl)-quinoline-4-carboxylic acid 
• 577-16-2 2-Methylacetophenone 
• 56962-08-4 4,5-dichlorophthalic acid 
• 855121-60-7 7-chloro-2-(4,5-dichloro-2-methyl-phenyl)-quinoline-4-carbonyl chloride 
• 855609-21-1 1-[7-chloro-2-(4,5-dichloro-2-methyl-phenyl)-[4]quinolyl]-2-diazo-ethanone 

Relevant articles and documents

Synthesis of substituted phenyl ketones via Pd-catalysed hydrodechlorination of their polychlorinated derivatives

The following compounds, 2- and 3-methylacetophenones, 2- and 3-methylbenzophenones, and 2,2'-, 2,3'- and 3,3'-dimethylbenzophenones have been synthesized through a Pd-catalysed hydrodechlorination of the corresponding dichlorinated derivatives. The reaction has been carried out under multiphase conditions at 30-50°C, by bubbling H2 at atmospheric pressure into a biphasic system constituted by an organic substrate solution (isooctane solvent) and an aqueous alkaline solution (50% aq KOH), in the presence of Pd/C (5% wt) and Aliquat 336 (tricaprylylmethylammonium chloride). Likewise, fluorinated aceto- and benzophenones (4-fluoro-3-methylacetophenone and 4-fluoro-3-methylbenzo-, 4-fluoro-2',3-dimethylbenzo-, 4-fluoro-3,3'-dimethylbenzophenones) have been prepared starting from the corresponding chlorinated methylfluoro and dimethyfluoro ketones. Under such conditions, the presence of the onium salt allows the reaction to proceed with a high chemoselectivity: chlorine is removed while both the reduction of the carbonyl group and/or fluorine removal are prevented.