53838-27-0

Basic information

• Product Name: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester
• Synonyms: AmbotzHAA6700
• CAS NO: 53838-27-0
• Molecular Formula: C10H19NO4
• Molecular Weight: 217.265
• Mol File: 53838-27-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester(53838-27-0)
• EPA Substance Registry System: L-Glutamic acid, 5-(1,1-dimethylethyl) 1-methyl ester(53838-27-0)

Safety Data

• Hazardous Substances Data: 53838-27-0(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 2419-56-9 L-glutamic acid 5-tert-butyl ester 
• 113408-54-1 trityl-glutamic acid-1-methyl ester 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 56-86-0 L-glutamic acid 
• 113408-53-0 N-trityl-L-glutamic acid dimethyl ester 
• 160002-61-9 N-(9-fluorenylmethoxycarbonyl)glutamic acid (O-tert-butyl) methyl ester 
• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 4124-76-9 N-(benzyloxycarbonyl)-L-glutamic acid anhydride 
• 5672-83-3 Z-L-GluOMe 
• 56877-41-9 methyl 2(S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonylbutanoate 

Downstream Products

• 115553-99-6 2(S),3'(S)-1-(3-amino-3-carboxypropyl)-5-oxo-2-pyrrolidinecarboxylic acid 
• 1219595-87-5 C₂₃H₃₄N₂O₉ 
• 294855-90-6 5-(2,5-dioxopyrrolidin-1-yl)-1-methylpalmitoyl L-glutamate 
• 73793-91-6 N-Hexadecanoyl-L-glutamic acid α-methyl ester 
• 1018929-92-4 5-tert-butyl-1-methyl ester ((S)-2-{[3-(4-nitro-benzenesulfonylamino)thiophene-2-carbonyl]amino})pentanedioate 
• 179682-17-8 4-(3-{1-[(S)-4-Methoxycarbonyl-4-(4-propyl-benzenesulfonylamino)-butyryl]-piperidin-4-yl}-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 179682-16-7 (S)-2-(4-Propyl-benzenesulfonylamino)-pentanedioic acid 1-methyl ester 
• 197969-50-9 (S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-{3-[6-(di-tert-butoxy-phosphoryloxy)-naphthalen-1-yl]-ureido}-butyric acid tert-butyl ester 
• 189393-64-4 (S)-4-[(3-Cyclohexyl-propyl)-methyl-carbamoyl]-4-[3-(6-hydroxy-naphthalen-1-yl)-ureido]-butyric acid tert-butyl ester 

Relevant articles and documents

Method for synthesizing glutamic acid-1-methyl ester-5-tert-butyl ester

The invention discloses a method for synthesizing glutamic acid-1-methyl ester-5-tert-butyl ester. The method comprises the following steps: generating dimethyl glutamate by using glutamic acid as aninitial raw material in methyl alcohol under the effect of thionyl chloride; reacting the dimethyl glutamate with triphenylchloromethane to generate dimethyl glutamate with triphenylmethyl protected amino; taking off methyl ester on the 5 position of the dimethyl glutamate with triphenylmethyl protected amino under the effect of sodium hydroxide to generate triphenylmethyl-glutamic acid-1-methyl ester; reacting the triphenylmethyl-glutamic acid-1-methyl ester-5-tert-butyl ester with trichloroacetic imine tert-butyl ester to generate triphenylmethyl-glutamic acid-1-methyl ester-5-tert-butyl ester, adding a small amount of triisopropylsilane into the triphenylmethyl-glutamic acid-1-methyl ester-5-tert-butyl ester in a low-concentration dichloromethane trifluoroacetate solution to take off triphenylmethyl to generate the glutamic acid-1-methyl ester-5-tert-butyl ester. The method is simple in operation, has few byproduct which can be extremely easy to treat and high product yield, and cansolve the problem of large operation difficulty in an existing synthesizing method.

Synthesis and immunomodulating activity of new glycopeptides of glycyrrhizic acid containing residues of L-glutamic acid

New glycopeptides of glycyrrhizic acid (GA) containing Glu residues and their α-methyl esters, γ-methyl esters, and α,γ-dimethyl esters were synthesized using N,N′-dicyclohexylcarbodiimide in the presence of N-hydroxybenzotriazole or N-hydroxysuccinimide.

TBAT-mediated nitrone formation of ω-mesyloxy-O-tert-butyldiphenylsilyloximes: Facile synthesis of cyclic nitrones from hemiacetals

Chiral and cyclic nitrones were synthesized by TBAT-mediated desilylative cyclization of ω-mesyloxy-O-tert-butyl-diphenylsilyloximes, readily prepared from sugar derivatives by a consecutive treatment with O-tert-butyldiphenylsilylhydroxylamine and with m