5384-13-4Relevant articles and documents
PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
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Page/Page column 73; 74, (2010/02/10)
Certain novel piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
Titanium Tetrachloride Induced Fries Rearrangement: A New Route to Disubstituted 2'-Hydroxypropiophenones
Martin, Robert,Demerseman, Pierre
, p. 25 - 28 (2007/10/02)
Fries rearrangement of some dialkylphenyl propionates with titanium tetrachloride proves to be a convenient route to hindered dialkyl 2'-hydroxypropiophenones.The sequential use of soft titanium tetrachloride to perform the Fries rearrangement followed by hard aluminum chloride to achieve the elimination of a protecting tert-butyl group allows the synthesis of some previously unknown 3',6'- and 5',6'-dialkyl-2-hydroxypropiophenones.