53897-27-1

Basic information

• Product Name: 4-Cyanobutanamide
• Synonyms: 4-Cyanobutanamide
• CAS NO: 53897-27-1
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.13
• Mol File: 53897-27-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 68-69 °C
• Boiling Point: 150-162 °C(Press: 0.5 Torr)
• Appearance: /
• Density: 1.065±0.06 g/cm3(Predicted)
• PKA: 16.28±0.40(Predicted)
• CAS DataBase Reference: 4-Cyanobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Cyanobutanamide(53897-27-1)
• EPA Substance Registry System: 4-Cyanobutanamide(53897-27-1)

Safety Data

• Hazardous Substances Data: 53897-27-1(Hazardous Substances Data)

Upstream product

• 544-13-8 Glutaronitrile 
• 41126-15-2 methyl 4-cyanobutanoate 
• 39201-33-7 4-cyanobutyric acid 

Downstream Products

• 675-20-7 piperidin-2-one 

Relevant articles and documents

Transfer Hydration of Dinitriles to Dicarboxamides

We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1, n -dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.

Synthesis of Nitriles from Aldoximes and Primary Amides Using XtalFluor-E

The dehydration reaction of aldoximes and amides for the synthesis of nitriles using [Et2NSF2]BF4 (XtalFluor-E) is described. Overall, the reaction proceeds rapidly (normally 1 h) at room temperature in an environmentally benign solvent (EtOAc) with only a slight excess of the dehydrating agent (1.1 equiv). A broad scope of nitriles can be prepared, including chiral nonracemic ones. In addition, in a number of cases, further purification of the nitrile after the workup was not required.