53902-59-3Relevant articles and documents
Formation of a 4-quinazolone on attempting to synthesize a symmetrical amedine of anthranilonitrile. Crystal structure of 3-(2-cyanophenyl)-4-quinazolone
Babaev,Bozhenko,Zhukov,Rybakov
, p. 964 - 967 (1997)
Attempts to synthesize a sym-diarylformamidine by the reaction of anthranilonitrile and its N-formyl derivative led to the formation of 3-(2-cyanophenyl)-4-quinazolone. The structure of the substance obtained was confirmed by x-ray analysis. 1998 Plenum P
THERAPEUTIC COMPOUNDS AND USES THEREOF
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Page/Page column 52; 85, (2019/07/17)
The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.
2-Amino[1,2,4]triazolo[1,5-c]quinazolines and Derived Novel Heterocycles: Syntheses and Structure–Activity Relationships of Potent Adenosine Receptor Antagonists
Burbiel, Joachim C.,Ghattas, Wadih,Küppers, Petra,K?se, Meryem,Lacher, Svenja,Herzner, Anna-Maria,Kombu, Rajan Subramanian,Akkinepally, Raghuram Rao,Hockemeyer, J?rg,Müller, Christa E.
, p. 2272 - 2286 (2016/10/25)
2-Amino[1,2,4]triazolo[1,5-c]quinazolines were identified as potent adenosine receptor (AR) antagonists. Synthetic strategies were devised to gain access to a broad range of derivatives including novel polyheterocyclic compounds. Potent and selective A3AR antagonists were discovered, including 3,5-diphenyl[1,2,4]triazolo[4,3-c]quinazoline (17, Kihuman A3AR 1.16 nm) and 5′-phenyl-1,2-dihydro-3′H-spiro[indole-3,2′-[1,2,4]triazolo[1,5-c]quinazolin]-2-one (20, Kihuman A3AR 6.94 nm). In addition, multitarget antagonists were obtained, such as the dual A1/A3antagonist 2,5-diphenyl[1,2,4]triazolo[1,5-c]quinazoline (13 b, Kihuman A1AR 51.6 nm, human A3AR 11.1 nm), and the balanced pan-AR antagonists 5-(2-thienyl)[1,2,4]triazolo[1,5-c]quinazolin-2-amine (11 c, Kihuman A1AR 131 nm, A2AAR 32.7 nm, A2BAR 150 nm, A3AR 47.5 nm) and 9-bromo-5-phenyl[1,2,4]triazolo[1,5-c]quinazolin-2-amine (11 q, Kihuman A1AR 67.7 nm, A2AAR 13.6 nm, A2BAR 75.0 nm, A3AR 703 nm). In many cases, significantly different affinities for human and rat receptors were observed, which emphasizes the need for caution in extrapolating conclusions between different species.