53912-89-3 Usage
Description
(+)-Anabasinehydrochloride, a hydrochloride analog of (S)-Anabasine (A637170), is a nicotinic receptor agonist. It is a chemical compound that interacts with nicotinic receptors, which are a subtype of receptors in the nervous system that respond to the neurotransmitter acetylcholine. This interaction can have various physiological effects depending on the specific receptor and its location within the body.
Uses
Used in Pharmaceutical Industry:
(+)-Anabasinehydrochloride is used as a research chemical for the development of new drugs targeting nicotinic receptors. Its agonistic properties allow it to modulate the activity of these receptors, which can be beneficial in the treatment of various neurological and neuromuscular disorders.
Used in Neurological Research:
(+)-Anabasinehydrochloride is used as a research tool in the study of nicotinic receptor function and its role in cognitive processes, such as memory and attention. Understanding the interactions between this compound and nicotinic receptors can provide insights into the development of therapeutic strategies for neurological conditions like Alzheimer's disease, Parkinson's disease, and schizophrenia.
Used in Neuromuscular Research:
(+)-Anabasinehydrochloride is used as a research compound to investigate the role of nicotinic receptors in neuromuscular transmission. This can help in the development of treatments for neuromuscular disorders, such as myasthenia gravis and muscular dystrophy, where impaired communication between nerves and muscles is a significant factor.
Used in Toxicology Studies:
(+)-Anabasinehydrochloride is used in toxicology research to study the effects of nicotinic receptor agonists on the body. This can help in understanding the potential risks and side effects associated with the use of such compounds in therapeutic applications.
Biological Activity
High affinity neuronal nicotinic ACh receptor partial agonist (K i values are 0.058, 0.26 and 7.2 μ M for rat α 7, rat α 4 β 2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca 2+ -dependent catecholamine release from rat adrenomedullary cells in vitro .
Check Digit Verification of cas no
The CAS Registry Mumber 53912-89-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,1 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 53912-89:
(7*5)+(6*3)+(5*9)+(4*1)+(3*2)+(2*8)+(1*9)=133
133 % 10 = 3
So 53912-89-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2.ClH/c1-2-7-12-10(5-1)9-4-3-6-11-8-9;/h3-4,6,8,10,12H,1-2,5,7H2;1H/t10-;/m0./s1
53912-89-3Relevant articles and documents
Spectroscopy and crystal structure of anabasine salts
Wojciechowska-Nowak, Marzena,Boczoń, W?adys?aw,Rychlewska, Urszula,Warzajtis, Beata
, p. 44 - 52 (2008/02/12)
The anabasinium hydrochloride, hydriodide and perchlorate were characterized by IR and NMR spectroscopy as well as by X-ray diffraction. Anabasinium hydrochloride crystallizes with three independent ionic pairs in the asymmetric part of the orthorhombic unit cell, while anabasinium hydriodide and perchlorate crystals, being isostructural, are hexagonal and contain only one symmetry independent ionic pair. Despite these differences in the crystal data, both types of crystals display very similar helical solid-state patterns. The reported results combined with the CSD searches indicate an inherent tendency of anabasinium salts to crystallize with multiple asymmetric units, and to form folded arrangements in crystals. In the solid state the anabasinium cations predominantly adopt either synperiplanar or antiperiplanar conformations with respect to the mutual orientation of C*-H and pyridine C-C(N) bonds, with deformations towards, respectively, (+) synclinal or (+) anticlinal rotamers.
Kohlenhydrate als chirale Matrices: Stereoselektive Tandem-Mannich-Michael-Reaktionen zur Synthese von Piperidin-Alkaloiden
Kunz, Horst,Pfrengle, Waldemar
, p. 1041 - 1042 (2007/10/02)
-
