53920-28-8

Basic information

• Product Name: 2-((4-bromophenyl)thio)acetyl chloride
• Synonyms: 2-((4-bromophenyl)thio)acetyl chloride
• CAS NO: 53920-28-8
• Molecular Weight: 265.558
• Mol File: 53920-28-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-((4-bromophenyl)thio)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-bromophenyl)thio)acetyl chloride(53920-28-8)
• EPA Substance Registry System: 2-((4-bromophenyl)thio)acetyl chloride(53920-28-8)

Safety Data

• Hazardous Substances Data: 53920-28-8(Hazardous Substances Data)

Upstream product

• 50397-69-8 (4-bromo-phenylsulfanyl)-acetic acid methyl ester 
• 65251-10-7 ethyl 2-((4-bromophenyl)thio)acetate 
• 3406-76-6 (4-bromophenylthio)acetic acid 

Downstream Products

• 250736-42-6 5-bromobenzo[b]thiophen-3(2H)-one 1,1-dioxide 
• 98632-02-1 (4-Bromo-phenylsulfanyl)-acetic acid 4-(2-{4-[2-(4-bromo-phenylsulfanyl)-acetoxymethyl]-3,5-dioxo-piperazin-1-yl}-ethyl)-2,6-dioxo-piperazin-1-ylmethyl ester 

Relevant articles and documents

Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis

Molecular motors undergo repetitive directional motions upon external energy input. A profound challenge is the defined transfer of directional motor motions to remote entities at the molecular scale. Herein, we present a molecular setup that allows for the transfer of the directional rotation of a light-powered motor unit onto a remote biaryl axis via an ethylene glycol chain link. Based on a combination of X-ray crystallographic analysis, ECD, and NMR experiments as well as a comprehensive theoretical assessment, we provide evidence for the coupled stepwise directional motions of both molecular units. With the presented setup, facile integration of molecular motor units into larger functional frameworks and complex molecular machines can be explored consciously in the future.

ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Synthesis and characterization of photoswitchable lipids containing hemithioindigo chromophores

The synthesis of four lipids containing the hemithioindigo chromophore as part of the fatty acid is described. Heck reaction of bromophenyl thioacetate esters with acrylonitrile, followed by reduction, ester hydrolysis, and Friedel-Craft acylation-cyclization gave a substituted thioindoxyl that condensed with an alkoxy benzaldehyde to produce the hemithioindigo. "Solventless" nitrile hydrolysis followed by mixed anhydride coupling of the acid with glycerophosphocholine produced lipids bearing two hemithioindigo chromophores. The photochemistry of various hemithioindigo derivatives was studied to confirm the expected photoisomerization in both homogeneous organic solution, and in vesicle bilayer membranes. Characteristic changes in the UV-visible spectra are consistent with fully reversible Z-E photoisomerization. Chromatographic separation of the Z and E isomers of a compound containing a single hemithioindigo chromophore confirmed the spectroscopic analysis and provided a quantitative analysis of the compositions of Z-E isomer mixtures.