53937-17-0 Usage
Description
Methyl 3-(3-iodo-4-methoxyphenyl)propanoate is a synthetic organic compound with the molecular formula C12H15IO3. It is an ester derived from the reaction of 3-(3-iodo-4-methoxyphenyl)propanoic acid and methanol. methyl 3-(3-iodo-4-methoxyphenyl)propanoate is characterized by the presence of an iodine atom and a methoxy group attached to a phenyl ring, which is connected to a propanoate group through an ester linkage.
Uses
Used in Organic Synthesis:
Methyl 3-(3-iodo-4-methoxyphenyl)propanoate is used as a synthetic intermediate for the introduction of the 3-(3-iodo-4-methoxyphenyl)propanoate moiety into other molecules. Its unique structure allows for various chemical reactions, making it a versatile building block in organic synthesis.
Used in Pharmaceutical Research:
In the pharmaceutical industry, methyl 3-(3-iodo-4-methoxyphenyl)propanoate is used as a key component in the synthesis of various pharmaceuticals and other organic compounds. Its iodine atom and methoxy group can be exploited for the development of new drugs with potential therapeutic applications.
Used in Laboratory Research:
Methyl 3-(3-iodo-4-methoxyphenyl)propanoate is also utilized in laboratory research for studying the properties and reactivity of organic compounds containing iodine and methoxy groups. It can provide insights into the synthesis and modification of complex organic molecules.
It is important to handle and use methyl 3-(3-iodo-4-methoxyphenyl)propanoate in accordance with standard laboratory practices and safety precautions to ensure the safety of researchers and the integrity of the experiments.
Check Digit Verification of cas no
The CAS Registry Mumber 53937-17-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,3 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 53937-17:
(7*5)+(6*3)+(5*9)+(4*3)+(3*7)+(2*1)+(1*7)=140
140 % 10 = 0
So 53937-17-0 is a valid CAS Registry Number.
53937-17-0Relevant articles and documents
Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source
Wu, Zhuo,Wei, Feng,Wan, Bin,Zhang, Yanghui
, p. 4524 - 4530 (2021/05/04)
A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.
SPIROCYCLIC CETP INHIBITORS
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Page/Page column 37, (2014/07/08)
Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing at
CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR
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Page/Page column 37, (2012/05/19)
CCompounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substitiuted phenyl group or indanyl group.Formula (I)
