53939-84-7

Basic information

• Product Name: 2-MERCAPTO-6-PROPYLPYRIMIDIN-4-OL
• Synonyms: TIMTEC-BB SBB003855;2-MERCAPTO-6-PROPYLPYRIMIDIN-4-OL;6-Butyl-2-thiouracil;6-Butyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-butyl-2-mercaptopyrimidin-4-ol
• CAS NO: 53939-84-7
• Molecular Formula: C₈H₁₂N₂OS
• Molecular Weight: 170.23
• EINECS: 200-103-2
• Mol File: 53939-84-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 218-221 °C
• Appearance: /
• CAS DataBase Reference: 2-MERCAPTO-6-PROPYLPYRIMIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MERCAPTO-6-PROPYLPYRIMIDIN-4-OL(53939-84-7)
• EPA Substance Registry System: 2-MERCAPTO-6-PROPYLPYRIMIDIN-4-OL(53939-84-7)

Safety Data

• Hazard Codes: Xn
• Statements: 40-22
• Safety Statements: 45-36/37
• Hazardous Substances Data: 53939-84-7(Hazardous Substances Data)

Upstream product

• 7737-62-4 Ethyl 3-oxoheptanoate 
• 17356-08-0 thiourea 
• 591-78-6 n-hexan-2-one 

Downstream Products

• 116137-73-6 2,4-dihydroxy-6-n-butylpyrimidine 
• 116137-73-6 6-(butyl)-1H-pyrimidin-4-one 
• 1394321-78-8 5-(4-butyl-6-oxo-1,6-dihydropyrimidin-2-ylamino)-2-methylbenzonitrile 
• 1328474-45-8 3-(4-butyl-6-oxo-1,6-dihydropyrimidin-2-ylamino)benzonitrile 
• 1328473-07-9 6-butyl-2-(4-fluorophenylamino)pyrimidin-4(3H)-one 
• 1394807-89-6 4-butyl-6-chloro-N-(4-fluorophenyl)pyrimidin-2-amine 

Relevant articles and documents

DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

Structure-Activity Relations. Part 12. Antibacterial Activity of a Series of 2,4-Diamino-6-substituted 5-(4-pyridylmethylamino)pyrimidines and 2,4-Diamino-5-(4-substituted benzylamino)pyrimidines.

A series of 6-substituted 2,4-diamino-5-(4-pyridylamino)pyrimidines and of 2,4-diamino-5-(4-substituted benzylamino)pyrimidines has been prepared.Their antibacterial activity towards L. casei, S. aureus and E. coli has been investigated.These activities have been successfully correlated by Hansch-type relations.Dependence on both lipophilicity and electronic (polar) factors has been found.The results are related to the structure and interactions with the receptor.