53940-12-8Relevant articles and documents
Luminescent Zn(ii) and Cd(ii) complexes with chiral 2,2′-bipyridine ligands bearing natural monoterpene groups: synthesis, speciation in solution and photophysics
Agafontsev, Alexander M.,Baranov, Andrey Y.,Bushuev, Mark B.,Glinskaya, Ludmila A.,Kokina, Tatyana E.,Komarov, Vladislav Y.,Plyusnin, Pavel E.,Rakhmanova, Marianna I.,Shekhovtsov, Nikita A.,Sheludyakova, Liliya A.,Tkachev, Alexey V.
, p. 7552 - 7563 (2020)
Mononuclear zinc(ii) and cadmium(ii) complexes, ZnLCl2(1), CdLCl2(2), ZnL1Cl2·2H2O (3), and CdL1Cl2·2H2O (4), with chiral ligands containing a 2,2′-bipyridine moiety and natural terpene (+)-limonene (L) or (+)-3-carene (L1) moieties were synthesized. In these complexes theLandL1ligands are shown to coordinate Zn2+and Cd2+ions through the 2,2′-bipyridine moiety. The acetamide group of the ligands interacts with M2+ions by forming N?M2+and C-O?M2+contacts and N-H?Cl hydrogen bonds with coordinated Cl?ions. In solutions the complexes have several conformers differing by the degree of the turn of the acetamide moiety relative to the ligand core and the type of its interaction with the coordination core. The ligands and complexes exhibit luminescence with the quantum yield increasing in the order: ligand 1-S0and T1-S0
An Efficient Cyclic Di-AMP Based Artificial Metalloribozyme for Enantioselective Diels–Alder Reactions
Qi, Qianqian,Lv, Shuting,Hao, Min,Dong, Xingchen,Gu, Youkun,Wu, Peizhe,Zhang, Wenyue,Chen, Yashao,Wang, Changhao
, p. 4417 - 4424 (2020/06/17)
The diverse structures of nucleic acids as scaffolds have brought the significant advancement for DNA-based enantioselective catalysis, yet RNA-based enantioselective catalysis is lacking investigation. Herein, we report a small, natural RNA of cyclic di-AMP (c-di-AMP) and Cu2+ ions assemble into an artificial metalloribozyme (c-di-AMP·Cu2+), that could effectively catalyze the enantioselective Diels–Alder reactions with up to 80 percent ee. The enantioselective catalytic performance of c-di-AMP·Cu2+ has been studied by thorough investigations of different metal cofactors, c-di-AMP/Cu2+ molar ratios, additives, buffers and c-di-AMP analogues. In addition, the assembly of c-di-AMP·Cu2+ gives rise to 300-fold and 5-fold rate acceleration compared to the uncatalyzed reaction and Cu2+ ions, respectively. This work provides a simple and efficient strategy to construct the RNA-based catalysts that would expand the current nucleic acids-based catalysis and might hint the possible catalytic RNA in primordial chemistry.
Basic Anion-Exchange Resin-Catalyzed Aldol Condensation of Aromatic Ketones with Aldehydes in Continuous Flow
Laroche, Benjamin,Saito, Yuki,Ishitani, Haruro,Kobayashi, Shū
supporting information, p. 961 - 967 (2019/05/02)
A general method for the aldol condensation of aromatic ketones with aldehydes was developed under continuous-flow conditions using a commercially available, strongly basic anion-exchange resin (A26) as catalyst. This procedure, in addition to exhibiting a wide substrate scope, promoted carbon-carbon bond formation under mild conditions using a quasi-stoichiometric ratio of starting reagents with good to excellent yields, thereby forming a limited amount of waste and allowing the process to be applied to sequential-flow systems. A proof of concept was developed in the first fully heterogeneously catalyzed two-step flow synthesis of donepezil, which is a blockbuster commercial anti-Alzheimer's drug.
