53960-10-4 Usage
General Description
4-OXO-3,4-DIHYDRO-PHTHALAZINE-1-CARBOXYLIC ACID METHYL ESTER, also known as N-Acetyl-4-hydroxyretinal, is a chemical compound that belongs to the class of phthalazine carboxylic acid esters. It is a methyl ester derivative of 4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid. 4-OXO-3,4-DIHYDRO-PHTHALAZINE-1-CARBOXYLIC ACID METHYL ESTER has potential pharmaceutical applications, particularly in the development of drugs targeting neurological disorders and cardiovascular diseases. It may also have potential uses in the field of organic synthesis and as a building block in the production of other chemical compounds. However, further research is required to fully understand the properties and potential uses of this chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 53960-10-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,6 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 53960-10:
(7*5)+(6*3)+(5*9)+(4*6)+(3*0)+(2*1)+(1*0)=124
124 % 10 = 4
So 53960-10-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2O3/c1-15-10(14)8-6-4-2-3-5-7(6)9(13)12-11-8/h2-5H,1H3,(H,12,13)
53960-10-4Relevant articles and documents
Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida albicans
Mood, Aaron D.,Premachandra, Ilandari Dewage Udara Anulal,Hiew, Stanley,Wang, Fuqiang,Scott, Kevin A.,Oldenhuis, Nathan J.,Liu, Haoping,Van Vranken, David L.
, p. 168 - 173 (2017/03/06)
Four phthalazinones (CIDs 22334057, 22333974, 22334032, 22334012) and one isoquinolone (CID 5224943) were previously shown to be potent enhancers of antifungal activity of fluconazole against Candida albicans. Several even more potent analogues of these compounds were identified, some with EC50 as low as 1 nM, against C. albicans. The compounds exhibited pharmacological synergy (FIC 0.5) with fluconazole. The compounds were also shown to enhance the antifungal activity of isavuconazole, a recently FDA approved azole antifungal. Isoquinolone 15 and phthalazinone 24 were shown to be active against several resistant clinical isolates of C. albicans.
