53960-31-9

Basic information

• Product Name: N-[4-chloro-2-(2-chlorobenzoyl)phenyl]formamide
• CAS NO: 53960-31-9
• Molecular Weight: 294.137
• Mol File: 53960-31-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-chloro-2-(2-chlorobenzoyl)phenyl]formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-chloro-2-(2-chlorobenzoyl)phenyl]formamide(53960-31-9)
• EPA Substance Registry System: N-[4-chloro-2-(2-chlorobenzoyl)phenyl]formamide(53960-31-9)

Safety Data

• Hazardous Substances Data: 53960-31-9(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 

Relevant articles and documents

Synthesis of N,N-dialkyl-9-oxoacridine-10(9H)-carbothioamides via the reaction of (2-halophenyl)(2-isothiocyanatophenyl)methanones with secondary amines, followed by cyclization with NaH

The first preparation of acridin-9(10H)-ones carrying a tertiary thiocarbamoyl group at C(10), i.e., N,N-dialkyl-9-oxoacridine-10(9H)- carbothioamides 9, is described. The method is based on the reaction of (2-halophenyl)(2-isothiocyanatophenyl)methanones 7, prepared from (2-aminophenyl)(2-halophenyl)methanones 5 by a convenient three-step sequence, with secondary amines in DMF at room temperature to generate the corresponding thiourea derivatives 8 in situ, which are treated with NaH at 100-120° to provide the desired products in one-pot reactions in generally good yields.