5397-16-0

Basic information

• Product Name: N-benzyl-2,4-dichlorobenzamide
• Synonyms: benzamide, 2,4-dichloro-N-(phenylmethyl)-
• CAS NO: 5397-16-0
• Molecular Formula: C₁₄H₁₁Cl₂NO
• Molecular Weight: 280.1492
• Mol File: 5397-16-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 424.3°C at 760 mmHg
• Flash Point: 210.4°C
• Density: 1.306g/cm³
• Vapor Pressure: 2.1E-07mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: N-benzyl-2,4-dichlorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2,4-dichlorobenzamide(5397-16-0)
• EPA Substance Registry System: N-benzyl-2,4-dichlorobenzamide(5397-16-0)

Safety Data

• Hazardous Substances Data: 5397-16-0(Hazardous Substances Data)

Upstream product

• 89-75-8 2,4-dichlorobenzoyl chloride 
• 100-46-9 benzylamine 
• 50-84-0 2,4 dichlorobenzoic acid 
• 180069-53-8 (E)-N-benzyl-1-(2,4-dichlorophenyl)methanimine 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 126571-89-9 N-(4-chlorosulfonylphenylmethyl)-2,4-dichlorobenzamide 
• 213475-01-5 {4-[(2,4-Dichloro-benzoylamino)-methyl]-benzenesulfonylamino}-acetic acid 
• 106841-13-8 N-benzyl-4-chloro-2-hydroxybenzamide 

Relevant articles and documents

Visible-Light-Mediated Synthesis of Amides from Aldehydes and Amines via in Situ Acid Chloride Formation

An efficient visible-light photocatalysis-based one-pot amide synthesis method was developed; visible-light irradiation of a mixture of an aldehyde, tert-butyl hydrogen peroxide, and N-chlorosuccinimide using a Ru(bpy)3Cl2 photocatalyst afforded an acid chloride, which subsequently reacted with amine to yield the corresponding amide. The reaction was used to synthesize moclobemide and a D3 receptor intermediate.

Oxidation of N-benzylaldimines to N-benzylamides by MCPBA and BF3·OEt2

N-Benzylamides were obtained from the corresponding N-benzylaldimines in high yields. N-Benzylaldimines are readily prepared from the corresponding aldehydes with benzylamine. This procedure involves the oxidation of N-benzylaldimines with MCPBA with BF3·OEt2. In this reaction, the reaction presumably follows an internal hydrogen abstraction to provide only N-benzylamide.

O,O-Diethyldithiophosphoric acid. A new condensing agent for acylation of amines by carboxylic acid

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