53981-69-4

Basic information

• Product Name: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL
• Synonyms: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL;Ethanone, 1-(1H-imidazol-2-yl)- (9CI);2-ACETYLIMIDAZOLE;1-(1H-imidazol-2-yl)ethanone(SALTDATA: FREE);1-(1H-Imidazol-2-yl)-1-ethanone
• CAS NO: 53981-69-4
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11394
• Product Categories: ACETYLGROUP
• Mol File: 53981-69-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 136-138℃
• Boiling Point: 269.4 °C at 760 mmHg
• Flash Point: 120.8 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0.00727mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.11±0.10(Predicted)
• CAS DataBase Reference: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL(53981-69-4)
• EPA Substance Registry System: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL(53981-69-4)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 53981-69-4(Hazardous Substances Data)

Usage

General Description

1-(1H-Imidazol-2-yl)-ethanone HCl, also known as 2-Imidazolyl ethanone hydrochloride, is a chemical compound with the molecular formula C5H7NO.HCl. It is a derivative of imidazole, a five-membered aromatic ring containing two nitrogen atoms. 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL is commonly used as a reagent in organic synthesis and pharmaceutical research. It is also used in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals. Its properties and structure make it suitable for various applications in the field of chemistry and biotechnology.

InChI:InChI=1/C5H6N2O/c1-4(8)5-6-2-3-7-5/h2-3H,1H3,(H,6,7)

Upstream product

• 22098-61-9 1-(1H-imidazol-2-yl)ethan-1-ol 
• 2466-76-4 N-Acetylimidazole 
• 127-19-5 N,N-dimethyl acetamide 
• 61278-81-7 1-(diethoxymethyl)-1H-imidazole 
• 75-16-1 methylmagnesium bromide 
• 31722-49-3 2-cyano imidazole 
• 1100723-54-3 (Z)-1-(2-phenylhydrazono)-1-(1H-1,2,3-triazol-1-yl)propanone 
• 1100723-55-4 (Z)-1-[2-(4-chlorophenyl)hydrazono]-1-(1H-1,2,3-triazol-1-yl)propanone 
• 1100723-57-6 (Z)-1-[2-(p-tolyl)hydrazono]-1-(1H-1,2,3-triazol-1-yl)propanone 
• 875553-56-3 1-(1-tosyl-1H-imidazol-2-yl)ethan-1-one 

Downstream Products

• 951214-13-4 (E)-N-(1-(1H-imidazol-2-yl)ethylidene)prop-2-en-1-amine 
• 875553-56-3 1-(1-tosyl-1H-imidazol-2-yl)ethan-1-one 
• 220335-33-1 dichlorodimethylbis(1-acetylimidazole)tin(IV) 
• 1360148-63-5 C₂₀H₂₃N₃O₃S₂ 
• 912962-83-5 3-(3-(2-acetylimidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide 
• 1394118-86-5 4-[1-(2-aminopyrimidin-4-yl)-3-methyl-1H-indazol-6-yl]-2-(1H-imidazol-2-yl)but-3-yn-2-ol 
• 317335-04-9 1-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)ethan-1-one 
• 1394119-14-2 4-[1-(2-aminopyrimidin-4-yl)-3-methyl-1H-indazol-6-yl]-2-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-yn-2-ol 
• 31271-10-0 6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate 

Relevant articles and documents

Generation and Lithiation of the Dimers of 6-(Dimethylamino)-1,4-diazafulvene. A Novel Synthesis of 2-Alkanoylimidazoles

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Gas-phase pyrolysis in organic synthesis: New route for synthesis of functionally substituted imidazoles

(Chemical Equation Presented) 1,2,3-Triazolylpropanone was prepared and coupled with aryldiazonium salts yielding the corresponding arylhydrazones. Gas-phase pyrolysis of the hydrazono derivative produced N-arylamino-2- acetylimidazole as well as 2-acetyl

ARYLOXY-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided. The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.