53983-15-6

Basic information

• Product Name: Ethyl 5-amino-4-phenylisoxazole-3-carboxylate
• Synonyms: 5-amino-4-phenyl-3-Isoxazolecarboxylic acid ethyl ester
• CAS NO: 53983-15-6
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.24
• Mol File: 53983-15-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 436.5°Cat760mmHg
• Flash Point: 217.8°C
• Appearance: /
• Density: 1.239g/cm³
• Vapor Pressure: 8.06E-08mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Ethyl 5-amino-4-phenylisoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-amino-4-phenylisoxazole-3-carboxylate(53983-15-6)
• EPA Substance Registry System: Ethyl 5-amino-4-phenylisoxazole-3-carboxylate(53983-15-6)

Safety Data

• Hazardous Substances Data: 53983-15-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H12N2O3/c1-2-16-12(15)10-9(11(13)17-14-10)8-6-4-3-5-7-8/h3-7H,2,13H2,1H3

Upstream product

• 1823-91-2 1-phenylethyl cyanide 
• 1134-71-0 ethyl 3-phenylbutanoate 

Downstream Products

• 109094-45-3 2-benzoylamino-3-phenyl-succinamic acid ethyl ester 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 96129-46-3 ethyl 4-phenylisoxazole-3-carboxylate 
• 127919-46-4 t-butyl [2-(5-amino-4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate 

Relevant articles and documents

Preparation method of 5-(substituted benzimido)-4-substituted phenylisoxazole-3-carboxylic ethyl ester derivatives

The invention discloses a preparation method of 5-(substituted benzimido)-4-substituted phenylisoxazole-3-carboxylic ethyl ester derivatives with antibacterial activity. The 5-(substituted benzimido)-4-substituted phenylisoxazole-3-carboxylic ethyl ester derivatives include compounds and stereoisomers and medically applicable salts of the compounds, wherein a structural formula of the compounds is as shown in the specification. The invention further discloses the 5-(substituted benzimido)-4-substituted phenylisoxazole-3-carboxylic ethyl ester derivatives and medically applicable acid addition salts thereof, wherein the medically applicable acid addition salts can be used with existing medicines or used independently. According to in-vitro tests, the 5-(substituted benzimido)-4-substituted phenylisoxazole-3-carboxylic ethyl ester derivatives are high in antibacterial activity and antituberculous activity and have a promising prospect in preparation of antituberculous medicines.