5399-48-4

Basic information

• Product Name: methyl octopyranoside
• CAS NO: 5399-48-4
• Molecular Formula: C₉H₁₈O₈
• Molecular Weight: 254.2344
• Mol File: 5399-48-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 595.5°C at 760 mmHg
• Flash Point: 313.9°C
• Density: 1.58g/cm³
• Vapor Pressure: 1.16E-16mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: methyl octopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: methyl octopyranoside(5399-48-4)
• EPA Substance Registry System: methyl octopyranoside(5399-48-4)

Safety Data

• Hazardous Substances Data: 5399-48-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 6291-04-9 D-erythro-L-galacto-octose 
• 7647-01-0 hydrogenchloride 
• 56570-93-5 D-erythro-L-galacto-Octono-1,4-lactone 
• 4082-97-7 D-threo-L-galacto-octose 
• 115520-91-7 methyl 2,3,4,6,7,8-hexa-O-acetyl-β-L-threo-D-manno-octopyranoside 
• 40653-15-4 methyl 2,3,4-tri-O-benzyl-α-D-manno-hexodialdo-1,5-pyranoside 
• 34212-64-1 methyl 2,3,4-tri-O-benzyl-α-D-mannopyranoside 
• 125287-97-0 methyl uronate 
• 125288-00-8 methyl (methyl-2,3,4-tri-O-benzyl-l-threo-α-D-manno-octopyranoside)uronate 
• 115520-89-3 methyl 2,3,4-tri-O-benzyl-β-L-threo-D-manno-octopyranoside 
• 115520-85-9 methyl 2,3,4-tri-O-benzyl-L-threo-β-D-gluco-oct-1,5-pyranoside 
• 53008-65-4 methyl 2,3,4-tri-O-benzyl-D-glucopyranoside 
• 83051-88-1 methyl 6-aldehydo-2,3,4-tri-O-benzyl-α-D-glucopyranoside 

Downstream Products

• 5329-49-7 (2S,3S,4S,5S,6R)-6-((1R,2S)-1,2,3-Trihydroxy-propyl)-tetrahydro-pyran-2,3,4,5-tetraol 
• 5329-49-7 (2S,3R,4S,5S,6R)-6-((1R,2S)-1,2,3-Trihydroxy-propyl)-tetrahydro-pyran-2,3,4,5-tetraol 

Relevant articles and documents

Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: Towards antivirulence molecules targeting lipopolysaccharide biosynthesis

L-Heptoses (L-glycero-D-manno-heptopyranoses) are constituents of the inner core of lipolysaccharide (LPS), a molecule playing key roles in the mortality of many infectious diseases as well as in the virulence of many human pathogens. The inhibition of the first enzymes of the bacterial heptose biosynthetic pathway is an almost unexplored field to date although it appears to be a very novel way for the development of antivirulence drugs. We report the synthesis of a series of D-glycero-D-manno-heptopyranose 7-phosphate (H7P) analogues and their inhibition properties against the isomerase GmhA and the the kinase HldE, the two first enzymes of the bacterial heptose biosynthetic pathway. The heptose structures have been modified at the 1-, 2-, 6- and 7-positions to probe the importance of the key structural features of H7P that allow a tight binding to the target enzymes; H7P being the product of GmhA and the substrate of HldE, the second objective was to find structures that could simultaneously inhibit both enzymes. We found that GmhA and HldE were extremely sensitive to structural modifications at the 6- and 7- positions of the heptose scaffold. To our surprise, the epimeric analogue of H7P displaying a D-glucopyranose configuration was found to be the best inhibitor of both enzymes but also the only molecule of this series that could inhibit GmhA (IC50=34 μM) and HldE (IC50=9.4 μM) in the low micromolar range. Noteworthy, this study describes the first inhibitors of GmhA ever reported, and paves the way to the design of a second generation of molecules targeting the bacterial virulence. Copyright