53995-57-6Relevant articles and documents
Synthesis, characterization and antibacterial activity of cobalt(III) complexes with pyridine-amide ligands
Mishra, Anurag,Kaushik, Nagendra K.,Verma, Akhilesh K.,Gupta, Rajeev
, p. 2189 - 2196 (2008)
The ligands 2-(N-(X-pyridyl)carbamoyl)pyridine (X = 2, 3 or 4 for HL1-HL3, respectively) and 2,6-bis(N-(Y-pyridyl)carbamoyl)pyridine (Y = 2, 3 or 4 for H2L4-H2L6, respectively) in their mono- and di-deprotonated forms have been used to synthesize kinetically stable cobalt(III) compounds [Co(L1-3)3] (1-3) and Na[Co(L4-6)2] (4-6), respectively. The Co(III) ion is in octahedral environment and is surrounded by three bidentate ligands in complexes 1-3 and two tridentate ligands in complexes 4-6. Ligands coordinate the cobalt center via amidic-N and pyridine-N centers forming a 5-membered chelate ring. Complexes 1-6 have thoroughly been characterized by the various spectroscopic analyses (1H NMR, 13C NMR, UV-vis, IR, mass), elemental analysis, and conductivity measurement. All complexes have been assayed for in vitro antimicrobial activity against clinically isolated resistant strains of Pseudomonas, Proteus, Escherichia coli and standard strains of Pseudomonas aeruginosa (MTCC 1688), Shigella flexneri (MTCC 1457), Klebsiella planticola (MTCC 2272). All cobalt compounds show mild to moderate activity. However, complexes [Co(L1)3] (1) and Na[Co(L4)2] (4) were found to have potent activity against standard and pathogenic resistant bacteria used in the study. Their MIC ranged from 2.7 to 187 μg/ml. In vitro toxicity tests demonstrated that all complexes were less cytotoxic than that of gentamycin on HEK cell lines and the results reveal that these complexes can act as potent antimicrobial agents.
N-(Pyridin-2-yl)picolinamide tetranickel clusters: Synthesis, structure and ethylene oligomerization
Wang, Kefeng,Shen, Miao,Sun, Wen-Hua
, p. 564 - 568 (2010)
A series of N-(pyridin-2-yl)picolinamide derivatives was synthesized and characterized. Tetranickel complexes were obtained by stoichiometric reaction of NiBr2 and corresponding ligands, and characterized by elemental and spectroscopic analysis. Moreover, the coordination pattern of complex 3a was confirmed by single-crystal X-ray diffraction. In the structure, two ligands linked two nickel atoms to form a unit, and two units were bridged via μ3-OMe and μ2-Br to form a tetranickel cluster. These Ni(II) complexes were investigated in ethylene oligomerization and found to exhibit remarkable catalytic activities upon activation with MAO. Reaction conditions as well as ligand environment significantly affected the catalytic performance of the nickel complexes; the highest activity could be achieved to be 2.7 × 106 g mol-1 Ni h-1.
Copper(I)-catalysed aerobic oxidative selective cleavage of C[sbnd]C bond with DMAP: Facile access to N-substituted benzamides
Ma, Haojie,Lu, Guoqiang,Han, Bo,Huang, Guosheng,Zhang, Yuqi,Wang, Ji-Jiang
supporting information, (2021/06/15)
A base/DMAP system for efficient oxidative cleavage of C(CO)–C(alkyl) bond to generate N-substituted benzamides has been developed in the presence of copper(I) chloride. The usage of inexpensive copper catalyst, broad substrate scope, mild conditions make
Mapping out the Relative Influence of Hydrogen and Halogen Bonds in Crystal Structures of a Family of Amide-Substituted Pyridines
Abeysekera, Amila M.,Day, Victor W.,Sinha, Abhijeet S.,Aaker?y, Christer B.
, p. 7399 - 7410 (2020/11/03)
The simultaneous use of hydrogen bonds and halogen bonds in crystal engineering strategies has previously been employed in order to generate new solid forms with applications in e.g. pharmaceutical and agrochemical industries. Unfortunately, it is not eas
