540-73-8 Usage
Description
1,2-Dimethyl hydrazine, also known as 1,2-dimethylhydrazine (SDMH), is a colorless or yellow hygroscopic liquid with an ammonia-like odor. It is less dense than water, has a flash point of 5°F, and is highly reactive, easily catching fire. It is a powerful DNA alkylating agent and a known carcinogen. 1,2-Dimethyl hydrazine is used primarily as a research chemical and has no known commercial uses, although it was once evaluated as a high-energy rocket fuel.
Uses
Used in Research Chemicals:
1,2-Dimethyl hydrazine is used as a research chemical for studying its properties and potential applications. It is used to induce colon cancer in laboratory rats and mice, providing valuable insights into the development and treatment of this type of cancer.
Used in Rocket Propellant Research:
Although there are no known commercial uses for 1,2-dimethyl hydrazine, it was once evaluated as a potential high-energy rocket fuel. This application is currently limited to research and development, as the compound is not used in the production of rocket propellants.
Used in the Production of Photographic Chemicals:
1,2-Dimethyl hydrazine is also used in the production of certain photographic chemicals, although the quantities produced for this purpose are likely to be much less compared to other hydrazine compounds.
Air & Water Reactions
Highly flammable. Fumes upon exposure to air . Soluble in water with evolution of heat.
Reactivity Profile
1，2-Dimethyl hydrazine dissolves, swells, and disintegrates many plastics [USCG, 1999].
Health Hazard
Breathing of vapor causes pulmonary irritation, delayed gastro-intestinal irritation, tremors, and convulsions. Contact with skin or mucous membranes causes chemical burns. Can be absorbed through skin to cause systemic intoxication and convulsions.
Health Hazard
Inhalation exposure to hydrazines, cause adverse health effects and poisoning to animals
and humans. The symptoms of toxicity and poisoning include, but are not limited to,
injury to the lungs, liver, kidney, vomiting, uncontrolled shaking, lethargy (sluggishness),
coma, and neuritis (an infl ammation of the nerves), convulsions, tremors, seizures, and the
CNS. Effects on the nervous system have also been seen in animals exposed to hydrazine
and 1,1-dimethylhydrazine, but not to 1,2-dimethylhydrazine.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by ingestion, intraperitoneal,
intravenous, subcutaneous, and
intramuscular routes. Moderately toxic by
inhalation. Human mutation data reported.
A very dangerous fire hazard when exposedto heat, flame, or oxidizers. A hgh-energy
propellant for liquid-fueled rockets. When
heated to decomposition it emits toxic
fumes of NOx
Carcinogenicity
SDMH is carcinogenic to mice,
rats, and hamsters using a variety of exposure routes. Oral
doses of 21 mg/kg for 11 weeks produced intestinal tumors
in rats. A lower dose (3 mg/kg) in drinking water for
12 months produced liver hemangioendotheliomas.A
number of these tumors were metastatic. Mice given
doses of 60–90 mg/day in drinking water developed a variety
of tumors including angiosarcomas and lung adenomas
. Both oral administration and intraperitoneal
injection increased lung adenomas in the A/J strain
mouse. Hamsters also developed angiosarcomas,
intestinal tumors, and liver tumors following average daily
intakes of 160 mg in drinking water. An in-depth
description of the uniqueness of the colonic tumors was
presented.
Check Digit Verification of cas no
The CAS Registry Mumber 540-73-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 540-73:
(5*5)+(4*4)+(3*0)+(2*7)+(1*3)=58
58 % 10 = 8
So 540-73-8 is a valid CAS Registry Number.
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