54013-18-2

Basic information

• Product Name: 5-chloro-2-(1H-tetrazol-5-yl)aniline
• Synonyms: 5-chloro-2-(1H-tetrazol-5-yl)aniline;5-Chloro-2-(1H-tetrazol-5-yl)benzenamine;Einecs 258-923-1;BenzenaMine, 5-chloro-2-(2H-tetrazol-5-yl)-;5-Chloro-2-(1H-tetrazol-5-yl)aniline 97%;5-Chloro-2-(1H-tetrazol-5-yl)aniline97%
• CAS NO: 54013-18-2
• Molecular Formula: C₇H₆ClN₅
• Molecular Weight: 195.60904
• EINECS: 258-923-1
• Mol File: 54013-18-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 436.5 °C at 760 mmHg
• Flash Point: 217.8 °C
• Appearance: /
• Density: 1.540
• Vapor Pressure: 8.02E-08mmHg at 25°C
• Refractive Index: 1.692
• PKA: 4.37±0.10(Predicted)
• CAS DataBase Reference: 5-chloro-2-(1H-tetrazol-5-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(1H-tetrazol-5-yl)aniline(54013-18-2)
• EPA Substance Registry System: 5-chloro-2-(1H-tetrazol-5-yl)aniline(54013-18-2)

Safety Data

• Hazardous Substances Data: 54013-18-2(Hazardous Substances Data)

Usage

General Description

5-chloro-2-(1H-tetrazol-5-yl)aniline is a chemical compound with the molecular formula C7H6ClN5. It is a chlorinated aniline derivative with a tetrazole ring substitution. 5-chloro-2-(1H-tetrazol-5-yl)aniline has potential applications in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. The presence of both the chloro and tetrazole moieties in its structure make it useful for pharmaceutical research and development. Additionally, it has been studied for its potential biological activities, including antiviral and antimicrobial properties. However, due to its chemical properties and potential biological activities, caution should be exercised in handling and using this compound in laboratory and industrial settings.

InChI:InChI=1/C7H6ClN5/c8-4-1-2-5(6(9)3-4)7-10-12-13-11-7/h1-3H,9H2,(H,10,11,12,13)

Upstream product

• 38487-86-4 2-amino-4-chlorobenzonitrile 
• 34662-32-3 4-chloro-2-nitrobenzonitrile 
• 92567-02-7 C₇H₄ClN₅O₂ 

Downstream Products

• 1034331-69-5 5-chloro-1H-indole-2-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1034331-58-2 6-chloro-2H-chromene-3-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1034331-13-9 (E)-N-[5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-3-(3,4-dichloro-phenyl)-acrylamide 
• 1034331-08-2 (E)-N-[5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-3-naphthalen-2-yl-acrylamide 
• 1034331-04-8 (E)-N-[5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-acrylamide 
• 1034331-74-2 6-bromo-2-oxo-2H-chromene-3-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1080029-22-6 N-[5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-3-(4-chloro-3-trifluoromethyl-phenyl)-3-oxo-propionamide 
• 1083418-92-1 4-methyl-2-pyridin-4-yl-thiazole-5-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1083418-57-8 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1083418-51-2 5-(4-chloro-phenyl)-2-methyl-furan-3-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1083418-29-4 5-(4-chloro-phenyl)-trifluoromethyl-furan-3-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1083418-31-8 1-(4-chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1083418-45-4 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1083418-75-0 4-methyl-2-morpholin-4-yl-thiazole-5-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 

Relevant articles and documents

Azosemide intermediate synthesizing method

The invention discloses an azosemide intermediate synthesizing method. The method comprises the steps of performing tetrazole reaction to prepare a compound A: warming and enabling 4-chlorin-2-nitro benzonitrile and sodium azide to react under action of a catalyst and extracting reaction liquid by water to obtain reaction liquid of the compound A; directly performing hydrogenation reaction to prepare a compound B; performing chlorosulfonation reaction to prepare a compound C: slowly dropping qualified compound B and chlorosulfonic acid into cold water after temperature reaction and center control qualification, extracting through an organic solvent, standing for layering and decompressing, evaporating and drying the solvent in an organic phase mode to obtain a compound crude product C; performing ammonolysis reaction to prepare a compound D. Compared with the prior art, raw materials of the method disclosed by the invention are easy to obtain and low in cost; the method is low in cost, convenient to operate, suitable for industrialization and little in generated three wastes; furthermore, comprehensive utilization of waste can meet national industrial policy.

Synthesis of diverse azolo[c]quinazolines by palladium(II)- catalyzed aerobic oxidative insertion of isocyanides

We report the palladium(II)-catalyzed aerobic oxidative coupling of isocyanides with various (2-aminophenyl)azoles using air as the stoichiometric oxidant. A diverse range of medicinally valuable azolo[c]quinazolines was obtained by this new approach.

DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS

The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.