54023-01-7

Basic information

• Product Name: 5-(3 4-DICHLOROPHENYL)-2-FURONIC ACID
• Synonyms: 5-(3 4-DICHLOROPHENYL)-2-FURONIC ACID;5-(3,4-Dichlorophenyl)-2-furoic acid 97%
• CAS NO: 54023-01-7
• Molecular Formula: C₁₁H₆Cl₂O₃
• Molecular Weight: 257.071
• Product Categories: API intermediates;FuransHeterocyclic Building Blocks;Building Blocks;Furans;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 54023-01-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 236-240 °C(lit.)
• Boiling Point: 425°C at 760 mmHg
• Flash Point: 210.8°C
• Appearance: /
• Density: 1.477g/cm³
• Vapor Pressure: 5.57E-08mmHg at 25°C
• Refractive Index: 1.604
• PKA: 2.83±0.10(Predicted)
• CAS DataBase Reference: 5-(3 4-DICHLOROPHENYL)-2-FURONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3 4-DICHLOROPHENYL)-2-FURONIC ACID(54023-01-7)
• EPA Substance Registry System: 5-(3 4-DICHLOROPHENYL)-2-FURONIC ACID(54023-01-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 54023-01-7(Hazardous Substances Data)

Usage

Description

5-(3,4-Dichlorophenyl)-2-furoic acid is an organic compound characterized by its chemical structure that features a dichlorophenyl group attached to a furoic acid backbone. This molecule is known for its potential applications in the pharmaceutical industry, particularly in the synthesis of therapeutic agents.

Uses

Used in Pharmaceutical Industry:
5-(3,4-Dichlorophenyl)-2-furoic acid is used as a reactant for the preparation of dantrolene (D185000), a drug with potential applications in treating vascular dysfunction. Dantrolene is known to help relax muscles and improve blood flow, making it a valuable compound for managing conditions related to vascular health.

InChI:InChI=1/C11H6Cl2O3/c12-7-2-1-6(5-8(7)13)9-3-4-10(16-9)11(14)15/h1-5H,(H,14,15)

Upstream product

• 88-14-2 2-furanoic acid 
• 95-76-1 m,p-dichloroaniline 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 54023-11-9 5-(3,4-dichloro-phenyl)-furan-2-carboxylic acid methyl ester 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 52130-34-4 5-(3,4-dichlorophenyl)furfural 

Downstream Products

• 61941-91-1 5-(3,4-dichloro-phenyl)-furan-2-carbonyl chloride 
• 795291-26-8 3-benzyl-6-[5-(3,4-dichlorophenyl)furan-2-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 

Relevant articles and documents

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

An efficient synthesis of N,N-Dialkyl-5-(chlorophenyl)-2-furancarbothioamides from 2-furoic acid

An efficient synthesis of N,N-dialkyl-5-(chlorophenyl)-2-furancarbothioamides from 2-furoic acid was performed under mild conditions as inhibitor candidates of plant growth. 5-(Chlorophenyl)-2-furoic acids (3a-d) were prepared by treating 2-furoic acid wi

Synthesis of some thiadiazolotriazinone derivatives as possible antimicrobial agents

A series of 7-substituted-3-t-butyl 4(H)-1,3,4-thiadiazolo(2,3-c)-1,2,4- triazine-4-one (3) have been synthesized by condensing 4-amino-6-t-butyl-3- mercapto-1,2,4-triazin-5(4H)-one (1) with substituted Arylfuroic acids (2) using POCl3 as a cyclizing agen