54032-88-1

Basic information

• Product Name: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester
• Synonyms: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester;Ethyl 4-methyl-2-(4-methoxyphenyl)thiazole-5-carboxylate
• CAS NO: 54032-88-1
• Molecular Formula: C₁₄H₁₅NO₃S
• Molecular Weight: 277.34
• Mol File: 54032-88-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester(54032-88-1)
• EPA Substance Registry System: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester(54032-88-1)

Safety Data

• Hazardous Substances Data: 54032-88-1(Hazardous Substances Data)

Usage

Molecular structure

Consists of a thiazole ring with a methyl and methoxyphenyl group attached, as well as an ethyl ester functional group.

Type of compound

Organic compound.

Potential biological activity

May have antifungal or antibacterial properties due to the presence of the thiazole ring in its structure.

Use in research

Commonly used in pharmaceutical and medicinal research as a building block for the synthesis of other compounds.

Drug candidate potential

Its biological activity and structural features make it a promising candidate for further investigation as a potential drug.

Pharmacokinetic properties

The ethyl ester functional group suggests that the compound can be easily modified to improve its pharmacokinetic properties, making it more suitable for drug development.

Upstream product

• 2362-64-3 p-methoxythiobenzamide 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 161797-99-5 (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) 
• 74-88-4 methyl iodide 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 3424-93-9 4-methoxyphenylacetamide 
• 84911-18-2 ethyl 2-bromoacetoacetate 

Downstream Products

• 952394-78-4 ethyl 4-(bromomethyl)-2-(4-methoxyphenyl)thiazole-5-carboxylate 
• 82875-44-3 2-(4-methoxyphenyl)-4-methylthiazole-5carboxamide 
• 1384111-05-0 C₁₆H₁₈N₂O₄S 
• 161797-99-5 (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.

miRNA biosynthesis inhibitor

The invention provides a compound shown as a formula I, or a conformational isomer thereof, or an optical isomer thereof, or a pharmaceutically acceptable salt thereof. The compound can be tightly combined with related binding proteins in an miRNA biosynthesis process and can effectively inhibit the synthesis of miRNA-21. The prepared active compound provided by the invention can be used as an miRNA-21 inhibitor, and further as a potential drug for treating malignant tumors. The formula I is shown in the description.

Biphenyl heterocyclic derivatives, their preparation and their use as medicaments (by machine translation)

The present invention relates to a novel biphenyl heterocyclic derivative represented by a general formula (I) and a preparation method thereof and use of a pharmaceutical composition containing the derivative for preparation of a drug for treating diabetes. The biphenyl heterocyclic derivative has extremely excellent hypoglycemic activity in vivo, and excellent in vivo safety and low liver toxicity risk of the compound having such a structure are unexpectedly found, and the novel biphenyl heterocyclic derivative may be used for preventing or treating diabetes.