5404-88-6

Basic information

• Product Name: 2 - Chloro - 6 - hydrazino - 7H - purine
• Synonyms: 2 - Chloro - 6 - hydrazino - 7H - purine;2-Chloro-6-hydrazinyl-9H-purine
• CAS NO: 5404-88-6
• Molecular Formula: C₅H₅ClN₆
• Molecular Weight: 184.5864
• Mol File: 5404-88-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 332.9°C at 760 mmHg
• Flash Point: 155.1°C
• Appearance: /
• Density: 2.15g/cm³
• Vapor Pressure: 0.000142mmHg at 25°C
• Refractive Index: 1.981
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2 - Chloro - 6 - hydrazino - 7H - purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2 - Chloro - 6 - hydrazino - 7H - purine(5404-88-6)
• EPA Substance Registry System: 2 - Chloro - 6 - hydrazino - 7H - purine(5404-88-6)

Safety Data

• Hazardous Substances Data: 5404-88-6(Hazardous Substances Data)

Usage

Description

2 Chloro 6 hydrazino 7H purine, also known as CHHP, is a purine derivative with the molecular formula C5H5ClN6. It is a synthetic compound that contains a chloro group and a hydrazino group. CHHP has been studied for its potential pharmacological properties, including antitumor and antiviral activities. It is also known for its ability to chelate metal ions and is being investigated for its potential use in metallopharmaceuticals. CHHP has shown promise in scientific research as a potential lead compound for the development of new drugs for various medical applications.

Uses

Used in Pharmaceutical Industry:
2 Chloro 6 hydrazino 7H purine is used as a potential lead compound for the development of new drugs due to its antitumor and antiviral activities.
Used in Metallopharmaceuticals:
2 Chloro 6 hydrazino 7H purine is used as a chelating agent for metal ions, which has potential applications in the development of metallopharmaceuticals.

InChI:InChI=1/C5H5ClN6/c6-5-10-3-2(8-1-9-3)4(11-5)12-7/h1-2H,7H2,(H,8,9,10,11,12)

Upstream product

• 5451-40-1 2,6-dichloro-7H-purine 
• 5451-40-1 2,6 dichloropurine 

Downstream Products

• 1681-15-8 2-chloro-9H-purine 
• 182127-23-7 2-chloro-6-p-chlorobenzylidenehydrazino-9H-purine 
• 182127-27-1 2-chloro-6-p-nitrobenzylidenehydrazino-9H-purine 
• 182127-28-2 2-chloro-6-p-hydroxybenzylidenehydrazino-9H-purine 
• 182127-22-6 2-chloro-6-p-fluorobenzylidenehydrazino-9H-purine 
• 182127-24-8 2-chloro-6-p-methoxybenzylidenehydrazino-9H-purine 

Relevant articles and documents

Green Regioselective Synthesis of (Purin-6-yl)hydrazones

Some unique purine hydrazinylidene derivatives were synthesized by the regioselective reaction of 2,6-dichloropurine with hydrazine hydrate, followed by condensation with commercially available 1,3-dicarbonyl compounds according to a green chemistry approach. The structures of the synthesized compounds were confirmed by 1H and 13C NMR, IR, and mass spectra and elemental analyses. The regioselectivity of chlorine substitution in 2,6-dichloropurine was established by HMBC (Heteronuclear Multiple Bond Correlation) NMR technique.

Reduction of different electron-poor N-heteroarylhydrazines in strong basic conditions

The first application of the Wolff-Kishner reduction methodology to electron-poor heteroaromatic compounds is reported. Hydrazino-containing heterocycles with hydrazone-type tautomery have been reduced under basic conditions. This novel chemistry was successfully applied to mono-dehalogenate a number of electron-poor heterocycles in a regioselective manner. According to the experimental results, this reductive process is a base-catalyzed reaction that takes only place in the presence of air, probably through an oxygen-assisted mechanism. As consequence of the specific features of this kind of hydrazone/enehydrazine tautomers, the overall outcome of the process is the synthesis of a Shapirotype reduction product by simply using a milder version of the Huang-Minlon methodology.