54049-23-9

Basic information

• Product Name: 4-hydroxyphenylhydrazine hydrochloride
• Synonyms: 4-hydroxyphenylhydrazine hydrochloride
• CAS NO: 54049-23-9
• Molecular Weight: 160.603
• Mol File: 54049-23-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-hydroxyphenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxyphenylhydrazine hydrochloride(54049-23-9)
• EPA Substance Registry System: 4-hydroxyphenylhydrazine hydrochloride(54049-23-9)

Safety Data

• Hazardous Substances Data: 54049-23-9(Hazardous Substances Data)

Upstream product

• 123-30-8 4-amino-phenol 

Downstream Products

• 112723-89-4 5-hydroxy-2,3-diphenylindole 
• 91444-54-1 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol 
• 198481-32-2 bazedoxifene 
• 869663-58-1 4-(5-amino-3-tert-butyl-pyrazol-1-yl)-phenol 
• 705934-28-7 4-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenol 
• 51642-26-3 2-nitro-4-azidophenol 

Relevant articles and documents

Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group

A regioselective synthesis of indoles from arylhydrazine hydrochlorides with alkynes and diethyl ketone catalyzed by a rhodium complex is described. A possible mechanism involving an in-situ generated oxidizing directing group -N-Ni'CR1R2 assisted ortho-C-H activation and reductive elimination are proposed. The catalytic reaction is highly compatible with a wide range of functional arylhydrazines and alkynes. The reaction proceeds under mild reaction conditions and is atom-step economical.