54049-24-0

Basic information

• Product Name: METHYL 7-BROMOHEPTANOATE
• Synonyms: METHYL 7-BROMOHEPTANOATE;7-BROMOHEPTANOIC ACID METHYL ESTER
• CAS NO: 54049-24-0
• Molecular Formula: C₈H₁₅BrO₂
• Molecular Weight: 223.11
• Mol File: 54049-24-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 229.2 °C at 760 mmHg
• Flash Point: 118.2 °C
• Appearance: /
• Density: 1.257
• Vapor Pressure: 0.0703mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 7-BROMOHEPTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 7-BROMOHEPTANOATE(54049-24-0)
• EPA Substance Registry System: METHYL 7-BROMOHEPTANOATE(54049-24-0)

Safety Data

• Hazardous Substances Data: 54049-24-0(Hazardous Substances Data)

Usage

General Description

Methyl 7-Bromoheptanoate is a chemical compound with the formula C8H15BrO2. It is a colorless liquid with a fruity odor and is commonly used as a flavoring agent in the food industry. It is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Methyl 7-Bromoheptanoate is flammable and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system. It should be stored in a cool, dry place away from direct sunlight and sources of ignition.

InChI:InChI=1/C8H15BrO2/c1-11-8(10)6-4-2-3-5-7-9/h2-7H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 30515-28-7 7-bromoheptanoic acid 
• 2041-15-8 1,3,5-cyclohexanetriol 
• 67-56-1 methanol 
• 20965-27-9 7-bromo-heptanonitrile 
• 629-30-1 1,7-heptandiol 
• 50816-19-8 8-bromooctanol 
• 10160-24-4 7-bromoheptyl alcohol 
• 124-41-4 sodium methylate 

Downstream Products

• 10160-24-4 7-bromoheptyl alcohol 
• 108545-34-2 7-(2-Nitro-phenylselanyl)-heptanoic acid methyl ester 
• 76453-33-3 methyl 1-benzyloxycarbonyl-3-(6-methoxycarbonyl)hexyl-2-oxo-4-imidazolidinecarboxylate 
• 76453-40-2 4-(1-Ethoxy-ethoxymethyl)-3-(6-methoxycarbonyl-hexyl)-2-oxo-imidazolidine-1-carboxylic acid benzyl ester 
• 77152-18-2 Methyl 7-phenylthioheptanoate 
• 63571-92-6 7-Phenoxy-Oenanthsaeure-methylester 
• 884490-88-4 7-{2-[4-(3-hydroxy-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid methyl ester 
• 884490-87-3 7-{2-[4-(3-cyano-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid methyl ester 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

A marine natural product (R, Z) - 24-methyl-twenty-five carbon -16-butene -2,4-diyne -1,6-diol and its antimer synthesis method

The invention relates to a synthetic method of a marine natural product namely (R, Z)-24-methyl-25-carbon-16-butylene-2,4-diyne-1,6-diol and an enantiomer thereof, and belongs to the field of chemical synthesis. The synthetic method comprises the following steps: firstly, preparing long chain alkyl iodide by using a series of simple reactions including bromination, oxidation, esterification, reduction and the like; and then, performing multiple steps of reactions including coupling, dislocation, oxidation, selective reduction, asymmetric alkynylation addition, esterification, hydrolysis and the like by taking propargyl alcohol and the long chain alkyl iodide as starting materials to synthesize the marine natural product namely (R, Z)-24-methyl-25-carbon-16-butylene-2,4-diyne-1,6-diol and the enantiomer thereof, wherein the key step is that trimethylsilylacetylene and alkynal are subjected to asymmetric addition reaction to generate alkynol segments with high optical purity by one step. The synthetic method provided by the invention reports the synthesis of the natural product of the type for the first time, and has the characteristics of simple and convenient steps, relatively high total yield, good product stereoselectivity and the like, and the optical purity of each of the two types of synthesized products is more than 99%ee.

A marine natural product (R) - 24-methyl-twenty-five carbon -2, 4, 16- three alkyne -1,6-diol and its antimer synthesis method

The invention discloses a synthetic method for a marine natural product (R)-24-methyl-pentacosa-2,4,16-trialkynyl-1, 6-diol and enantiomer thereof, which belongs to the field of chemical synthesis. According to the invention, propargyl alcohol is used as a starting material, and a plurality of steps of reactions like coupling, transposition, oxidation, selective reduction, asymmetric alkynylation addition, esterification and hydrolysis are carried out to synthesize the marine natural product and enantiomer thereof; a key step is that trimethyl silicon-based acetylene and alkynal undergo asymmetric addition so as to produce a high-optical purity alkynol fragment in one step; and long-chain iodoalkane added in the process of synthesis is prepared through a series of simple reactions including bromination, oxidation, esterification, reduction and the like, so reaction route is greatly shortened. The synthesis of the natural product provided by the invention is reported for the first time; the synthetic method has the characteristics of simple steps, high total yield, good product stereoselectivity, etc.; and the optical purities of the products with two configurations are both greater than 99% ee.