54054-63-6

Basic information

• Product Name: N-(2,6-dimethylphenyl)-2-methylprop-2-enamide
• CAS NO: 54054-63-6
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.2536
• Mol File: 54054-63-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 333°C at 760 mmHg
• Flash Point: 197.9°C
• Density: 1.034g/cm³
• Vapor Pressure: 0.000141mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: N-(2,6-dimethylphenyl)-2-methylprop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-dimethylphenyl)-2-methylprop-2-enamide(54054-63-6)
• EPA Substance Registry System: N-(2,6-dimethylphenyl)-2-methylprop-2-enamide(54054-63-6)

Safety Data

• Hazardous Substances Data: 54054-63-6(Hazardous Substances Data)

Upstream product

• 87-62-7 2,6-dimethylaniline 
• 920-46-7 Methacryloyl chloride 

Downstream Products

• 111875-35-5 N-benzoylformyl-N-(2,6-xylyl)methacrylamide 
• 84243-49-2 2-methyl-1-[2-methyl-2-[(2,6-dimethylphenyl)carbamoyl]ethyl]-2-imidazoline 
• 72991-80-1 1,2-bis(2',6'-dimethylphenyl-amino)-2-methyl-propane 

Relevant articles and documents

Versatile One-Pot Synthesis of Polysubstituted Cyclopent-2-enimines from α,β-Unsaturated Amides: Imino-Nazarov Reaction

The imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imines was realized. To this aim, a one-pot procedure involving reductive alkenyliminylation of α,β-unsaturated secondary amides with potassium organotrifluoroborates, followed by acid-catalyzed imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imine intermediates, was studied systematically. This mild, operationally simple, flexible, and high-yielding protocol efficiently affords polysubstituted pentan-1,4-diene-3-imines, cyclopentenimines, and α-amino cyclopentenones, which are useful scaffolds in organic synthesis. The substituent effect at the C2 position of the polysubstituted pentan-1,4-diene-3-imines was studied by means of density-functional theory calculations. Results suggested that the electron-donating group facilitates the imino-Nazarov cyclization process.